Purpose: Morphine infusion through Intrathecal Drug Delivery System (IDDS) is widely used to relieve refractory cancer pain. However, continuous escalation of morphine dose caused by opioid tolerance and/or progress of cancer was commonly observed. Combining morphine with medications of different analgesic mechanisms is applied to blunt the rate of morphine increase. The purpose of this study was to determine the analgesic efficacy and safety of combining gabapentin with morphine after IDDS implantation.
Methods: This study compared patients that received IDDS implantation from January 1, 2017 to November 10, 2018 in our institute. Key outcomes included change in mean pain score, dose of morphine used in patients, percentage of patients with 30% and 50% reduction in mean pain score, Patient Global Impression of Change scores, breakthrough pain characters and side effects.
Results: 34 patients in the combination group (morphine + gabapentin) and 40 patients in the monotherapy group(morphine)were analyzed. The results showed that both therapy groups achieved similar analgesic efficacy, demonstrated by Numerical rating scale (2.42 ± 0.88 vs 2.57 ± 0.85; Combination vs Monotherapy), PGIC and responder status. Mean daily dose of morphine was significantly lower in combination group compared to monotherapy group (3.54 ± 1.29 mg vs 4.64 ± 1.28 mg, P = 0.007). More patients experienced dizziness and somnolence after receiving combination therapy compared to morphine-alone treatment although no statistical significance was found (P = 0.49).
Conclusion: Addition of gabapentin achieved similar analgesic efficacy with lower dose of morphine compared to morphine alone accompanying with higher incidence of dizziness and somnolence.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00520-021-06350-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A meta-analysis of the efficacy and safety of aspirin in the treatment of elderly patients with sepsis.
Pak J Pharm Sci
January 2025
Department of Intensive Care Medicine, Putuo Central Hospital, Shanghai, China.
This study aimed to use meta-analytic techniques to evaluate aspirin's safety and effectiveness in treating elderly patients with sepsis. We searched PubMed, Embase, The Cochrane Library, Web of Science and Medline databases for relevant literature, screened and extracted key data and Stata 12.0 was used for comprehensive analysis.
View Article and Find Full Text PDFAtropine plus omeprazole for acute gastritis: Efficacy and safety analysis.
Pak J Pharm Sci
January 2025
Jian'ou Municipal Hospital, Nanping, Fujian, China.
Article Synopsis
- The article evaluates the effectiveness and safety of a combination treatment of atropine (ATR) and omeprazole (OME) for acute gastritis (AG) in comparison to anisodamine (ADM) with OME.
- The study involved 95 patients, with the ATR+OME group showing a higher success rate, fewer side effects, and quicker symptom relief than the ADM+OME group.
- Results indicated that the ATR+OME treatment significantly reduced inflammatory markers and gastrointestinal hormone levels, suggesting its strong efficacy and safety for managing AG, making it suitable for wider clinical use.
Nebulized dexmedetomidine in the treatment of obstetric post-dural puncture headache: two case reports.
BMC Anesthesiol
January 2025
Department of Anesthesiology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Post-dural puncture headache (PDPH) is a debilitating complication of neuraxial anesthesia, particularly prevalent in obstetric patients, usually characterized by a postural headache. PDPH is hypothesized to result from cerebrospinal fluid leakage through a dural puncture, triggering symptoms like neck stiffness and subjective hearing changes. While conservative measures are common for treatment, more refractory cases may require invasive interventions such as an epidural blood patch (EBP).
View Article and Find Full Text PDFSynergistic Effects of NO/HS Gases on Antibacterial, Anti-inflammatory, and Analgesic Properties in Oral Ulcers Using a Gas-Releasing Nanoplatform.
Acta Biomater
January 2025
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, P. R. China. Electronic address:
Article Synopsis
- Oral mucosal wounds are susceptible to inflammation and complications due to exposure to microorganisms, which can hinder daily activities and diminish quality of life.
- A novel therapeutic nanoplatform, DATS@Arg-EA-SA, has been developed to target these wounds by combining guanidinated dendritic peptides with diallyl trisulfide (DATS), providing both antimicrobial and anti-inflammatory effects.
- This nanoplatform effectively eliminates various bacteria, including drug-resistant strains like MRSA, and enhances healing by promoting the transition of inflammatory cells and alleviating pain, making it a promising solution for oral wound treatment.
Meta-Analysis of Palmitoylethanolamide in Pain Management: Addressing Literature Gaps and Enhancing Understanding.
Nutr Rev
January 2025
Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria, Pozuelo, Spain.
Article Synopsis
- Chronic pain affects many people, and Palmitoylethanolamide (PEA) is highlighted as a natural and safe pain management alternative that works through the endocannabinoid system, inflammation modulation, and immune regulation.
- A meta-analysis of 18 randomized clinical trials with 1,196 patients was conducted to assess the effectiveness of PEA in reducing various types of pain, showing significant pain reduction at multiple time points (6, 8, and 24-26 weeks).
- The analysis confirmed that PEA not only alleviates pain for nociceptive, neuropathic, and nociplastic types but also improves overall quality of life, with benefits noticeable within the
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!