Indirect calorimetry (IC)-guided nutrition might positively affect the clinical outcome of critically ill patients. In this systematic review and meta-analysis, our objective was to assess the benefit of isocaloric nutrition guided by IC, compared to hypocaloric nutrition, for critically ill patients admitted to the intensive care unit (ICU). We performed a systematic review of all randomized controlled trials published through January 2021, assessing the benefit of isocaloric nutrition guided by IC. The primary outcome was 28-day all-cause mortality. Secondary outcomes were ICU and 90-day all-cause mortality, rate of nosocomial infections, and adverse events. Four trials evaluating 1052 patients were included. Patients treated with isocaloric nutrition had a lower 28-day mortality rate (risk ratio (RR) 0.79, 95% confidence interval (CI) 0.63-0.99, P = 0.04). No between-group difference was found in ICU and 90-day mortality (RR 0.92, 95% CI 0.68-1.23, P = 0.56 and RR 0.88, 95% CI 0.72-1.07; P = 0.2, respectively) and in the rate of nosocomial infections (RR 1.15, 95% CI 0.77-1.72, P = 0.51). A pooled analysis of studies that evaluated the benefit of isocaloric nutrition guided by IC, for critically ill patients in the ICU, has shown reduced 28-day mortality. However, there was no difference in 90-day mortality and nosocomial infection rate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/s41430-021-00919-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Protein supplementation delivered alone or in combination with presumptive azithromycin treatment for enteric pathogens did not improve linear growth in Bangladeshi infants: results of a cluster-randomized controlled trial.
Am J Clin Nutr
January 2025
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
Background: Protein requirements established for healthy populations may be insufficient to support healthy growth in infants consuming largely cereal-based complementary foods and frequently exposed to enteric pathogens.
Objective: To assess independent and combined effects of protein supplementation and antibiotic treatment on linear growth of infants from 6-12 months of age.
Design: We conducted a 2 x 4 factorial cluster-randomized trial in northwestern Bangladesh, allocating 566 clusters to masked azithromycin (10 mg·kg * 3 d) or placebo at 6 and 9 months of age, and unmasked delivery of an egg white protein-rich blended food supplement (250 kcal; 10 g added protein), a rice-based isocaloric supplement, egg, or nutrition education from 6-12 months.
Efficacy of myo-inositol and zinc on insulin resistance in a paediatric population with obesity.
Diabetes Obes Metab
January 2025
Unit of Pediatrics Department of Health Sciences, Università del Piemonte Orientale, Novara, Italy.
Aim: To assess the efficacy of the combined administration of myo-inositol and zinc, a mineral involved in the insulin pathway, in paediatric obesity with insulin resistance on HOMA-IR, glucose-insulin metabolism, and lipid profile.
Materials And Methods: Double-blind, randomized, placebo-controlled study conducted in North Italy. Fifty-six patients (10-18 years, Tanner stage ≥3) with obesity and insulin resistance were randomized to myo-inositol (2000 mg), zinc gluconate (5 mg), and galactooligosaccharides (GOS) from plant-based origin (1000 mg) (TRT) or placebo (PLC) containing only GOS from plant-based origin (1000 mg).
Bambara Bean Substitution Improves the Nutritional Content and Increases the Satiety Index of Purple Sweet Potato Bread.
Prev Nutr Food Sci
December 2024
Department of Community Nutrition, Faculty of Human Ecology, IPB University, Bogor 16680, Indonesia.
This study aimed to develop tuber bread from purple sweet potato and bambara beans with high satiety and low glycemic index (GI). Different ratios of purple sweet potato to bambara bean were used: 100:0 (F0), 80:20 (F1), 60:40 (F2), and 40:60 (F3). The satiety index (SI) was determined by assessing the consumption of a 240 kcal isocaloric food and collecting data through a visual analog scale.
View Article and Find Full Text PDFEvaluation of growth, nutrient utilization, and metabolic function in rohu, Labeo rohita (Hamilton), fed diets incorporated with fermented Saraca asoca leaf meal.
Fish Physiol Biochem
January 2025
Aquaculture Laboratory, Department of Zoology, The University of Burdwan, Golapbag, Burdwan, 713104, West Bengal, India.
The present study evaluated the potential of Ashoka, Saraca asoca leaf meal (SLM), in carp diets following fermentative processing with a tannase-producing fish gut bacterium, Bacillus subtilis (KP765736). The processing of SLM led to a significant (P < 0.05) reduction in major anti-nutrients (tannin, trypsin inhibitor, and crude fiber), while crude protein content increased.
View Article and Find Full Text PDFDifferences in appetite, food intake, and gastric emptying responses to protein intake by older adults varying in level of physical activity: A randomised controlled trial.
Appetite
December 2024
School of Food and Nutritional Sciences, University College Cork, Cork, T12 Y337, Ireland. Electronic address:
Older adults are encouraged to increase their protein intake and engage in more physical activity to preserve muscle mass. However, since protein is considered the most satiating macronutrient, this advice might lead to a decrease in overall energy consumption. Physical activity is also recommended to older adults to enhance appetite, as it has been shown to help regulate appetite in younger adults, yet there is limited evidence to support this in older populations.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!