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[Preparation of injectable anticancer drugs within chemotherapy preparation unit: What levers are available to optimize and secure production?].
Bull Cancer
March 2023
CHU de la Réunion - Site Sud, service pharmacotechnie, pharmacie, BP 350, 97448 Saint-Pierre, Réunion.
Preparation of injectable anticancer drugs is centralized within chemotherapy preparation unit of hospital pharmacies under pharmaceutical responsibility. Improving the chemotherapy preparation unit's efficiency in the face of increasing demand, resource constraints and the need to ensure high quality is a challenge. Hospital pharmacists in search of efficiency in order to combine productivity and quality, have several tools to respond to this problem.
View Article and Find Full Text PDFComputerization during the antineoplastic compounding process guarantees greater adherence to evidence-based medicine for the prophylaxis of chemotherapy-induced nausea and vomiting.
Recenti Prog Med
June 2021
Department of Oncology, Mater Salutis Hospital, Az. ULSS 9 Scaligera, Legnago (VR), Italy.
Increasing pharmacy productivity and reducing medication turnaround times in an Italian comprehensive cancer center by implementing robotic chemotherapy drugs compounding.
J Oncol Pharm Pract
March 2022
Loccioni, Ancona, Italy.
Introduction: The management of antineoplastic drugs used for chemotherapy is widely recognized as a high-risk activity. In 2018, our oncology pharmacy implemented workflow improvements to manage the growing workload due to the centralisation of activities from a hospital's satellite pharmacy, moving towards automated compounding of antineoplastic drugs.The aim of this study was to determine the impact of the centralization on the productivity of the pharmacy department and evaluate the performances of the robotic chemotherapy drugs compounding.
View Article and Find Full Text PDFPediatric blinatumomab preparation: Risk assessment on SmPC for software compliance.
J Oncol Pharm Pract
October 2021
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Introduction: Blinatumomab is an anticancer drug used in the treatment of Acute Lymphoblastic Leukaemia (ALL) in both adults and children. ALL is the most common form of cancer in children and patients who are refractory to standard treatments have poor prognosis. The preparation of blinatumomab is unique and extremely complex.
View Article and Find Full Text PDFMultiparameter Phase I trials: a tool for model-based development of targeted agent combinations--example of EVESOR trial.
Future Oncol
February 2016
EMR UBCL/HCL 3738, Université Claude Bernard Lyon-1, Lyon, France.
Optimal development of targeted drug combinations is one of the future challenges to be addressed. Computerization and mathematical models able to describe biological phenomena and to simulate the effects of changes in experimental conditions may help find solutions to this issue. We propose the concept of 'multiparameter trials', where biological, radiological and clinical data required for modeling purpose are collected and illustrated by the ongoing academic EVESOR trial.
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