Hydroxyl radical is a significant player in oxidative DNA damage in vivo.

Chem Soc Rev

Department of Biochemistry, National University of Singapore, Centre for Life Sciences, #05-01A, 28 Medical Drive, 117456, Singapore.

Published: August 2021

Recent publications have suggested that oxidative DNA damage mediated by hydroxyl radical (˙OH) is unimportant in vivo, and that carbonate anion radical (CO˙) plays the key role. We examine these claims and summarize the evidence that ˙OH does play a key role as an important member of the reactive oxygen species (ROS) in vivo.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8328964PMC
http://dx.doi.org/10.1039/d1cs00044fDOI Listing

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