AI Article Synopsis
- Monoamine transporter occupancy in the brain, specifically for antidepressants, can be tracked using positron emission tomography (PET).
- For antidepressant effects to occur, serotonin transporter (SERT) occupancy needs to be at least 80%.
- There's a lack of clarity on the necessary norepinephrine transporter (NET) occupancy for antidepressant effects, highlighting the need for studies to find a balance between SERT and NET occupancy for effective treatment.
Article Abstract
Monoamine transporter occupancy of antidepressants in the brain can be measured by positron emission tomography. For antidepressive effects to appear, serotonin transporter (SERT) occupancy should rise to 80% or higher. Despite a recent increase in the number of reports on norepinephrine transporter (NET) occupancy, estimating the threshold level of NET occupancy required for antidepressive effects is difficult based on the analysis of NET alone. Therefore, studies should be conducted on NET occupancy required for a valid treatment, including an ideal balance between SERT and NET occupancy. (Received 24 September 2020; Accepted December 18, 2020; Published June 1, 2021).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.11477/mf.1416201823 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!