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Effects of Recording Condition and Number of Monitored Days on the Discriminative Power of the Daily Phonotrauma Index.
J Speech Lang Hear Res
January 2025
Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston.
Purpose: The Daily Phonotrauma Index (DPI) can quantify pathophysiological mechanisms associated with daily voice use in individuals with phonotraumatic vocal hyperfunction (PVH). Since DPI was developed based on weeklong ambulatory voice monitoring, this study investigated if DPI can achieve comparable performance using (a) short laboratory speech tasks and (b) fewer than 7 days of ambulatory data.
Method: An ambulatory voice monitoring system recorded the vocal function/behavior of 134 females with PVH and vocally healthy matched controls in two different conditions.
Spontaneous Cloacal Prolapse in a Farm Ostrich (Struthio camelus): Case Management and Literature Review.
Vet Med Sci
January 2025
Department of Surgery and Obstetrics, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
Captive ratites, including the ostrich (Struthio camelus), are susceptible to various gastrointestinal conditions. However, spontaneous cloacal prolapse is a relatively less frequent diagnosis. This report details the clinical management of cloacal prolapse in an ostrich, including a brief literature review.
View Article and Find Full Text PDF"INSERT-COIN": A PROSPECTIVE STUDY OF COIN INGESTION IN CHILDREN OF SOUTHERN ITALY.
Am J Gastroenterol
December 2024
Pediatric Clinic, Department of Surgical and Biomedical Sciences, University of Perugia, 06123 Perugia, Italy.
Background And Aims: Coins are the most commonly ingested foreign bodies. When they get stuck in the distal esophagus there is no general agreement about the timing of their removal, since some of them may spontaneously migrate into the stomach, no longer requiring removal. We aimed at evaluating the gastric spontaneous passage of esophageal-retained coins, as well as complications.
View Article and Find Full Text PDFImmune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes.
Cancer Res
December 2024
Rutgers, The State University of New Jersey, New Brunswick, NJ, United States.
Mutations in the exonuclease domains of the replicative nuclear DNA polymerases POLD1 and POLE are associated with increased cancer incidence, elevated tumor mutation burden (TMB), and enhanced response to immune checkpoint blockade (ICB). Although ICB is approved for treatment of several cancers, not all tumors with elevated TMB respond, highlighting the need for a better understanding of how TMB affects tumor biology and subsequently immunotherapy response. To address this, we generated mice with germline and conditional mutations in the exonuclease domains of Pold1 and Pole.
View Article and Find Full Text PDFRetained Surgical Sponge Expelled Through a Rectal Fistula With Spontaneous Passage Per Rectum.
Am Surg
January 2025
Department of General Surgery, University of Health Sciences Ankara Training and Research Hospital, Ankara, Türkiye.
Gossypiboma is a condition that occurs as a result of leaving sterile gauze, surgical sponges, or similar materials inadvertently retained in the body following surgery. The most common localization of gossypibomas is the intraabdominal cavity. Patients with gossypiboma can remain asymptomatic for years.
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