Noncatalyzed, regio- and stereoselective hypochlorite oxidation of 3-aminothieno[2,3-]pyridine-2-carboxamides is presented. Unexpectedly, the oxidation proceeded by different mechanistic pathways, and different products were formed, depending on the nature of solvents used. A possible mechanism, the structure of products, kinetics and dynamics of intramolecular processes, and biological activity of products are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8190813 | PMC |
| http://dx.doi.org/10.1021/acsomega.1c00341 | DOI Listing |
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