AI Article Synopsis
- * HLA typing is a quick and cost-effective process, but understanding the peptides presented to T cells on MHC-I and II requires advanced methods and comprehensive databases.
- * Recent advancements in identifying immunogenic peptides are explored, with discussions on future steps for translating this research into practical biomedical applications, including vaccine development and prioritizing high-risk HLA types.
Article Abstract
Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to many diseases such as cancer, auto-immune or infectious diseases. Individual genetic variation may help to explain different immune responses to microorganisms across a population. HLA typing can be fast and inexpensive; however, deciphering peptides loaded on MHC-I and II which are presented to T cells, require the design and development of high-sensitivity methodological approaches and subsequently databases. Hence, these novel strategies and databases could help in the generation of vaccines using these potential immunogenic peptides and in identifying high-risk HLA types to be prioritized for vaccination programs. Herein, the recent developments and approaches, in this field, focusing on the identification of immunogenic peptides have been reviewed and the next steps to promote their translation into biomedical and clinical practice are discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8195621 | PMC |
| http://dx.doi.org/10.3389/fcimb.2021.642583 | DOI Listing |
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