Antiproliferative and antibacterial activity of extracts of strains grown in vitro.

In this bioprospecting study the biological activities of extracts of the in vitro culture of Mexican strains were evaluated. The extracts were tested by the Sulforhodamine B staining method for antiproliferative activity and the plate microdilution method for antibacterial activity. Extracts that proved bioactive in these two activities, the antioxidant activity (Galvinoxyl, ABTS, and DPPH) and total phenolic contents (Folin-Ciocalteu) were additionally determined, as well as acute toxicity (). In the antiproliferative activity strain (GH-16-015) obtained a remarkable value of GI ≤ 50 µg/mL against tumor lines: A549, HBL-100, HeLa, and T-47D. . strains (GH-16-012 and GH-16-015) showed MIC values = 500 µg/mL against . . strain (GH-16-012) almost reduced by 50% the radical Galvinoxyl. Finally, strain (GH-16-023) presented the lowest level of toxicity with a LC of 490.881 µg/mL against . . These results support the potential medicinal effects of Mexican strains of . .