Malaria is one of the top 10 leading causes of death in Uganda. Short-term medical missions (STMMs) to address unmet medical needs in lower-resource settings are increasingly common. Th is study evaluates correlations between patient and clinician variables and accurate malaria diagnosis by providers on STMMs to Uganda. We surveyed 18 U.S. providers and performed a retrospective chart review of 246 patients seen by those providers on STMMs in Uganda between 2016 to 2017. All providers recorded their clinical level of suspicion for patients who met inclusion criteria, following which a rapid diagnostic test (RDT) was performed. Fift y-four percent of the patients tested positive for malaria. Level of provider accuracy ranged widely from 30.0% to 95.5% correct. Our fi ndings reaffirm that signs and symptoms of malaria are too nonspecifi c to be used alone without diagnostic testing by STMM providers. Pre-departure STMM training on malaria diagnosis is a necessity.
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http://dx.doi.org/10.1353/hpu.2021.0108 | DOI Listing |
Comput Biol Med
January 2025
Department of Mathematics and Computer Science, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy.
Background: Malaria is a critical and potentially fatal disease caused by the Plasmodium parasite and is responsible for more than 600,000 deaths globally. Early and accurate detection of malaria parasites is crucial for effective treatment, yet conventional microscopy faces limitations in variability and efficiency.
Methods: We propose a novel computer-aided detection framework based on deep learning and attention mechanisms, extending the YOLO-SPAM and YOLO-PAM models.
Globally, an estimated 2.1 billion malaria cases and 11.7 million malaria deaths were averted in the period 2000-2022.
View Article and Find Full Text PDFJ Biomed Opt
February 2025
National Institute of Standards and Technology, Applied Physics Division, Boulder, Colorado, United States.
Significance: Developments of anti-gametocyte drugs have been delayed due to insufficient understanding of gametocyte biology. We report a systematic workflow of data processing algorithms to quantify changes in the absorption spectrum and cell morphology of single malaria-infected erythrocytes. These changes may serve as biomarkers instrumental for the future development of antimalarial strategies, especially for anti-gametocyte drug design and testing.
View Article and Find Full Text PDFActa Med Indones
October 2024
Department of Parasitology, Faculty of Medicine Universitas Islam Indonesia, Yogyakarta, Indonesia.
Background: Papua is a high-endemic region for malaria in Indonesia. Malaria transmission is heavily influenced by environmental factors, particularly those related to vector breeding habitats and the homes of infected individuals. Communities in high-endemic areas also exhibit risk behaviors that can increase the likelihood of malaria transmission.
View Article and Find Full Text PDFActa Med Indones
October 2024
Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
In 2023, Indonesia's Ministry of Health reported that nearly 75% of districts and cities in the country were free from malaria transmission, meaning 90% of the population lived in malaria-free zones. However, Papua Province, which accounts for only 1.5% of Indonesia's population, continues to contribute over 90% of the national malaria cases, with more than 16,000 reported cases in 2023.
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