AI Article Synopsis
- The study investigates the survival rates of patients with mild secondary mitral regurgitation (SMR) compared to those without valvular abnormalities.
- It includes a retrospective analysis of over 16,000 patients and finds that those with mild SMR and mild tricuspid regurgitation (TR) have a significantly higher risk of death.
- The results suggest that even in patients with preserved left-ventricular ejection fraction (LVEF), mild SMR should be closely monitored due to its impact on survival.
Article Abstract
Background: Mild secondary mitral regurgitation (SMR) is considered clinically benign when left-ventricular ejection fraction (LVEF) is preserved, but evidence on survival associated with mild SMR in normal LVEF is limited.
Methods: We conducted a retrospective cohort study of patients who underwent echocardiography in a health care network between 2013 and 2018. We compared the survival of 4 groups: no valvular abnormalities (group 1), trace SMR with trace or mild tricuspid regurgitation (TR) (group 2), mild SMR with trace or no TR (group 3), and mild SMR with mild TR (group 4). A Cox proportional hazard model evaluated hazard of death in groups 2 to 4 compared with group 1, adjusting for demographics, comorbidities, and LVEF. The same comparisons were repeated in a subgroup of patients with preserved LVEF.
Results: Among the 16,372 patients of mean age 61 (51 to 71) years and 48% women, there were 8132 (49.7%) group 1 patients, 1902 (11.6%) group 2 patients, 3017 (18.4%) group 3 patients, and 3321 (20.3%) group 4 patients. Compared with group 1, group 4 had significantly increased adjusted hazard of death (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.12-1.31; P < 0.001), whereas groups 2 and 3 did not show a significantly different hazard of death. In those with preserved LVEF, the hazard was also significantly higher in group 4, compared with group 1 (HR, 1.14; 95% CI, 1.03-1.26; P = 0.013).
Conclusions: Mild SMR with mild TR, irrespective of LVEF, was associated with worse survival compared with patients without any valvular abnormalities. Patients with mild SMR may require closer monitoring, even with normal LVEF.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cjca.2021.06.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Understanding the Association Between Type 2 Diabetes Mellitus and Cognitive Impairment: A Single-centre Experience.
Ann Neurosci
June 2024
Department of Medicine, Government Medical College, Rajamahendravaram, Andhra Pradesh, India.
Background: The global prevalence of diabetes mellitus has been increasing, leading to a rise in morbidity associated with the disease. While diabetic nephropathy, retinopathy and neuropathy are routinely screened in diabetic patients, the cognitive decline associated with diabetes is often overlooked.
Purpose: The purpose of this study is to investigate the prevalence of cognitive impairment and its associated risk factors among patients with type 2 diabetes mellitus (T2DM).
Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function.
JACC Cardiovasc Interv
November 2024
St. Francis Hospital and Heart Center, Roslyn, New York, USA; Cardiovascular Research Foundation, New York, New York, USA.
Background: Outcomes of mitral transcatheter edge-to-edge repair (MTEER) in patients with secondary mitral regurgitation (sMR) and preserved left ventricular ejection fraction (LVEF) are uncertain.
Objectives: This study sought to describe outcomes of MTEER for sMR with preserved LVEF.
Methods: Using the STS/ACC TVT (Society of Thoracic Surgeons-American College of Cardiology Transcatheter Valve Therapy) Registry, we evaluated the risk-adjusted outcomes of MTEER for sMR with LVEF >50% by the severity of residual mitral regurgitation (MR), and we compared these outcomes to patients undergoing MTEER for sMR with LVEF of 20% to 50%.
Impact of Accidental High or Low Implantation Depth on Peri-Procedural Outcomes after Implantation with the Self-Expanding ACURATE neo2.
J Clin Med
September 2024
Department of Cardiology, St. Johannes Hospital, 44137 Dortmund, Germany.
Article Synopsis
- Precise implantation depth is crucial for the success of transcatheter aortic valve replacement (TAVR), but the effects of incorrect depths on the ACURATE NEO2 prosthesis hadn't been previously studied.
- A study of 1,839 patients evaluated outcomes based on three implantation depth categories: high (<3 mm), optimal (3-7 mm), and low (>7 mm), finding no significant differences in technical success or paravalvular regurgitation rates.
- While higher implantation showed better hemodynamics, it also had a higher risk of embolization; low implantation led to more pacemaker needs, suggesting it's better to avoid high placements to minimize risks.
Potentially avoidable mortality among adults with intellectual disability.
Eur J Public Health
December 2024
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Persons with intellectual disabilities (ID) face pronounced health disparities. The aim of this study was to describe premature mortality by causes of death and avoidable mortality among persons with ID compared to the general Danish population. This study is based on a Danish nationwide cohort of adults (aged 18-74 years) with ID (n = 57 663) and an age- and sex-matched reference cohort (n = 607 097) which was established by linkage between several registers.
View Article and Find Full Text PDFWater-soluble silver nanoclusters with multicolor fluorescence generated by dialdehyde nanofibrillated cellulose for biological imaging.
Carbohydr Polym
July 2024
Plant Fiber Material Science Research Center, State Key Laboratory of Pulp and Paper Engineering, School of Light Industry and Engineering, South China University of Technology, Guangzhou 510640, China.
Water-soluble silver nanoclusters (AgNCs) as a new type of fluorescent material have attracted much attention for their remarkable optical properties and excellent cytocompatibility. However, it is still challenging to synthesize water-soluble AgNCs with good cytocompatibility and excellent fluorescence. Herein, the dialdehyde nanofibrillated cellulose (DANFC)- reduced water-soluble AgNCs capped by glutathione (GSH) with tunable fluorescence emissions were first reported.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!