AI Article Synopsis
- - Propofol, a common anesthetic, requires dosage adjustment based on aging, and researchers hypothesize that telomere length (TL) could help predict the appropriate dose needed, especially in elderly patients.
- - In a study involving 100 surgical patients, researchers analyzed the correlation between propofol dosage and factors such as TL, body weight, sex, and changes in the Bispectral Index (BIS) during anesthesia, finding a strong connection with TL (r = 0.78).
- - The study concluded that TL is a significant factor in predicting propofol dosage, which could enhance anesthesia safety and decrease complications, while mutations in the telomerase RNA component (TERC) were not detected. *
Article Abstract
Introduction: Propofol is a widely used anesthetic and its dose is closely related to aging. Telomere length (TL) is a unique heritable trait, and emerging as a biomarker of aging, health and disease. Telomerase RNA component (TERC) plays an important role in maintaining TL. We proposed a hypothesis that propofol dose in general anesthesia can be predicted by measuring TL before operation, which greatly reduced the risk of anesthesia, especially the elderly.
Methods: The association between the propofol dose in anesthesia induction and: TL in the DNA of peripheral blood leukocytes; body weight; sex; difference of the Bispectral Index (BIS) before and after anesthesia induction in patients was evaluated by multivariable linear regression analyses. The mutation at the 5'end or 3'end of TERC was detected. We recruited 100 patients of elective surgery.
Results: We found that propofol dose in anesthesia induction was clearly correlated significantly with TL (r = 0.78, p < 0.001), body weight (r = 0.84, p = 0.004), sex (r = 0.83, p= 0.84, p = 0.004), sex (r = 0.83, p = 0.004), and difference of BIS before and after anesthesia induction (r = 0.85, p = 0.029). By comparing the absolute values of standardized regression coefficients (0.58, 0.21, 0.19, and 0.12) of the four variables, it can be seen that TL contributes the most to the propofol dose in anesthesia induction. However, the mutation at the 5' end or 3' end of TERC was not found.
Conclusions: These findings provide preliminary evidence that the propofol dose in anesthesia induction was clearly correlated with genetically determined TL. TL may be a promising predictor of the propofol dose, which is beneficial to improve the safety of anesthesia and reduce perioperative complications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10625149 | PMC |
| http://dx.doi.org/10.1016/j.bjane.2021.05.014 | DOI Listing |
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Article Synopsis
- The study focused on the effectiveness of propofol versus dexmedetomidine in reducing emergence delirium (ED) in pediatric patients after anesthesia, finding a wide incidence range (2% to 80%).
- Eighty children aged 2-6 undergoing short surgeries were treated with either propofol or dexmedetomidine before surgery, with ED assessed using specific scales afterward.
- Results showed a significantly lower ED rate in the dexmedetomidine group (2.5% vs. 70%), along with reduced postoperative pain, indicating that dexmedetomidine is more effective than propofol for these patients.
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