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| http://dx.doi.org/10.1016/j.kint.2021.06.006 | DOI Listing |
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Infiltrating macrophages and interferon gamma rather than renal genotype dictate heightened crescentic glomerulonephritis.
Front Immunol
January 2025
Department of Rheumatology, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Background: Both intrinsic renal cells and immune cells contribute to driving renal inflammation and damage. However, the respective roles of intrinsic renal cells and immune cells in crescentic glomerulonephritis, and the key molecular factors driving pathogenesis are still unclear.
Methods: The roles of intrinsic renal cells and renal infiltrating immune cells in crescent formation were explored using renal transplantation after experimental anti-GBM disease induction in 129x1/svJ and C57BL/6J mice.
Atypical anti-GBM disease in pregnancy.
BMJ Case Rep
November 2024
Kidney Health Service Metronorth, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
A woman in her 20s presented with nephrotic syndrome and hyperemesis in early pregnancy. Pertinent initial investigations revealed a severe acute kidney injury, a serum albumin of 19 g/L, a random protein creatinine ratio of 800 g/mol and microscopic haematuria. All immunological and infection serology testing including anti-glomerular basement membrane (anti-GBM; ELISA) were negative.
View Article and Find Full Text PDFManagement of immune-mediated glomerular diseases in the elderly.
Ren Fail
December 2024
S.C.D.U. Nefrologia, Dialisi e Trapianto, ARNAS Brotzu, Cagliari, Italy.
Article Synopsis
- Managing immune-mediated kidney diseases in elderly patients (≥75 years) is challenging due to age-related health issues and comorbidities.
- Current classification systems and treatment guidelines are insufficient for this age group, necessitating a more tailored approach.
- Treatment often involves immunosuppressive therapies, but careful drug choice and dosage are essential to minimize side effects, requiring a collaborative and patient-centered management strategy.
Anti-glomerular basement membrane disease complicated by malaria during pregnancy with successful maternal and fetal outcomes: a case report.
J Nephrol
December 2024
Department of Nephrology, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200, Pakistan.
Article Synopsis
- Acute kidney injury during pregnancy is fairly common, but anti-GBM disease is a rare cause, as illustrated by a 30-year-old woman who experienced impaired kidney function during her pregnancy.
- A kidney biopsy revealed she had crescentic glomerulonephritis due to anti-GBM antibodies, which prompted aggressive treatment including steroids and plasma exchange, leading to improvement in her kidney function.
- Despite the successful treatment, the patient developed malaria later in pregnancy, resulting in complications that required an emergency cesarean section, but she ultimately delivered a healthy baby at 33 weeks.
Outcome of rituximab treatment in children with non-dialysis-dependent anti-GBM disease.
Pediatr Nephrol
February 2025
Department of Pediatrics, Dr. v. Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany.
Article Synopsis
- Anti-GBM disease is a rare and serious condition characterized by the body producing antibodies that attack a specific type of collagen in the kidneys, leading to quick kidney failure if not treated.
- Current treatment guidelines recommend using plasma exchanges and drugs like steroids and cyclophosphamide, but cyclophosphamide can have severe side effects, prompting the search for alternatives like rituximab and mycophenolate mofetil.
- A study analyzing five adolescent patients treated with rituximab and mycophenolate mofetil found promising results, with 80% showing preserved or improved kidney function after treatment, suggesting these alternatives may be less toxic and effective.
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