As opioid overdose deaths increase, buprenorphine/naloxone (B/N) treatment is expanding, yet almost half of patients are not retained in B/N treatment. Mindfulness-based interventions (MBIs) designed to promote non-judgmental awareness of present moment experience may be complementary to B/N treatment and offer the potential to enhance retention by reducing substance use and addressing comorbid symptoms. In this pilot study, we examined the feasibility and acceptability of the Mindful Recovery OUD Care Continuum (M-ROCC), a trauma-informed, motivationally sensitive, 24-week MBI. Participants (N = 18) were adults with Opioid Use Disorder prescribed B/N. The study team conducted assessments of satisfaction, mindfulness levels, and home practice, as well as qualitative interviews at 4 and 24-weeks. M-ROCC was feasible in a sample with high rates of childhood trauma and comorbid psychiatric diagnoses with 89% of participants retained at 4-weeks and 72% at 24-weeks. Positive qualitative interview responses and a high rate of participants willing to refer a friend (100%) demonstrates program acceptability. Participant mindfulness increased from baseline to 24-weeks (β = 0.24, p = 0.001, d = 0.51), and increases were correlated with informal mindfulness practice frequency (r = 0.7, p < 0.01). Although limited by small sample size, this pilot study highlights the feasibility and acceptability of integrating MBIs into standard primary care Office-Based Opioid Treatment (OBOT) among a population with substantial trauma history.
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http://dx.doi.org/10.1016/j.jsat.2021.108415 | DOI Listing |
Sci Rep
December 2024
Department of Orthodontics, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
This research evaluated the effectiveness of an online simulation-based serious game as a learning tool in diagnosis and treatment planning for oral lesions (SimOL) in comparison to a pre-recorded lecture-based approach and to determine its appropriate integration into the undergraduate dental curriculum. A crossover randomized control trial was conducted with a cohort of 77 dental undergraduates. They were randomly assigned into two groups.
View Article and Find Full Text PDFArch Bone Jt Surg
January 2024
Center for Health Outcomes and Interdisciplinary Research (CHOIR), Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA.
Objectives: Traumatic orthopedic injuries are a top cause of hospital visits in the U.S. The Toolkit for Optimal Recovery (TOR) is a brief mind-body intervention that targets catastrophic thinking and pain anxiety following orthopedic injury.
View Article and Find Full Text PDFInt J Hematol
December 2024
Oncology, GSK, Upper Providence, PA, USA.
DREAMM-11 (NCT03828292) was a Phase 1, open-label, dose-escalation study of belantamab mafodotin in Japanese patients with relapsed/refractory multiple myeloma (RRMM). In Part 1, belantamab mafodotin monotherapy (2.5 or 3.
View Article and Find Full Text PDFCureus
November 2024
Orthopaedics, Gandhi Medical College, Bhopal, Bhopal, IND.
Background Pronator quadratus (PQ) acts as the pronator of the wrist and stabiliser of the distal radioulnar joint; it also provides a protective cover over the edge of the plate, preventing friction and subsequent rupture of flexor tendons. The repair of PQ is often difficult, and its durability is questionable; hence, preserving the PQ while volar plating distal radius fractures is advocated. Methods In this prospective randomised trial, 60 patients with a fracture of the distal end of the radius of AO-type (Arbeitsgemeinschaft für Osteosynthesefragen) 23 A2, A3, B1, B3, C1, and C2 were treated with volar plate fixation using either the PQ-releasing and repair approach (Group A, n = 30) or the PQ-sparing approach (Group B, n = 30), allowed by simple randomisation.
View Article and Find Full Text PDFNeurooncol Adv
October 2024
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Ependymomas of the spinal cord are rare among children and adolescents, and the individual risk of disease progression is difficult to predict. This study aims to evaluate the prognostic impact of molecular typing on pediatric spinal cord ependymomas.
Methods: Eighty-three patients with spinal ependymomas ≤22 years registered in the HIT-MED database (German brain tumor registry for children, adolescents, and adults with medulloblastoma, ependymoma, pineoblastoma, and CNS-primitive neuroectodermal tumors) between 1992 and 2022 were included.
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