Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes.

Genomics Proteomics Bioinformatics

BGI-Shenzhen, Shenzhen 518083, China; Shenzhen Key Laboratory of Human Commensal Microorganisms and Health Research, BGI-Shenzhen, Shenzhen 518083, China. Electronic address:

Published: April 2022

AI Article Synopsis

  • The study analyzed metagenomic data from vaginal, fecal, and salivary samples of over 1,100 Chinese women to explore the microbiome's composition, dominated by lactobacilli, and its influencing factors.
  • Factors like pregnancy history, delivery method, and breastfeeding were found to be more significant than menstrual cycle in shaping the microbial community in the vagina.
  • The research also identified potential health markers related to menstrual irregularities and overall well-being, emphasizing the need for international collaboration to further understand the microbiome's impact on female reproductive health beyond infections or pre-term births.

Article Abstract

The vagina contains at least a billion microbial cells, dominated by lactobacilli. Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age, as well as cervical, fecal, and salivary samples from a second cohort of 632 women. Factors such as pregnancyhistory, delivery history, cesarean section, and breastfeeding were all more important than menstrual cycle in shaping the microbiome, and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data. Greater proportion of Bifidobacterium breve was seen with older age at sexual debut. The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history. Potential markers for lack of menstrual regularity, heavy flow, dysmenorrhea, and contraceptives were also identified. Lactobacilli were rare during breastfeeding or post-menopause. Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome. Gut and salivary microbiomes, plasma vitamins, metals, amino acids, and hormones showed associations with the vagino-cervical microbiome. Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9684086PMC
http://dx.doi.org/10.1016/j.gpb.2021.01.005DOI Listing

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