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| http://dx.doi.org/10.5694/mja2.51135 | DOI Listing |
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Immune thrombocytopenia (ITP) is an autoimmune disorder marked by a low platelet count, leading to symptoms ranging from mild to severe bleeding. It can be triggered by various factors, including idiopathic origins, medications, malignancies, infections, and other autoimmune conditions. Though rare, ITP can also occur postvaccination.
View Article and Find Full Text PDFThe Effect of Vaccination on the Competitive Advantage of Two Strains of an Infectious Disease.
Bull Math Biol
January 2025
Department of Mathematics and Computer Science, Lawrence Technological University, 21000 W. 10 Mile Rd., Southfield, MI, 48075, USA.
We investigate the impact of differential vaccine effectiveness, waning immunity, and natural cross-immunity on the capacity for vaccine-induced strain replacement in two-strain models of infectious disease spread. We focus specifically on the case where the first strain is more transmissible but the second strain is more immune-resistant. We consider two cases on vaccine-induced immunity: (1) a monovalent model where the second strain has immune escape with respect to vaccination; and (2) a bivalent model where the vaccine remains equally effective against both strains.
View Article and Find Full Text PDFModeling COVID-19 dynamics in the Basque Country: characterizing population immunity profile from 2020 to 2022.
BMC Infect Dis
January 2025
Basque Center for Applied Mathematics, Bilbao, Bizkaia, Spain.
Background: COVID-19, caused by SARS-CoV-2, has spread globally, presenting a significant public health challenge. Vaccination has played a critical role in reducing severe disease and deaths. However, the waning of immunity after vaccination and the emergence of immune-escape variants require the continuation of vaccination efforts, including booster doses, to maintain population immunity.
View Article and Find Full Text PDFPotential use of salivary TNF-α as a vaccine-induced pain biomarker in people with cerebral palsy and communication disorders.
PLoS One
December 2024
Research Institute on Health Sciences (IUNICS-IdISBa), University of the Balearic Islands, Palma de Mallorca, Spain.
Article Synopsis
- Pain in individuals with cerebral palsy (CP) is often underestimated and inadequately managed, particularly in those with communication challenges.
- A study analyzed changes in salivary metabolites and pain behaviors in adults with CP compared to healthy adults after a painful procedure, revealing that CP subjects exhibited higher pain levels despite stable stress biomarkers.
- The findings suggest that sTNF-α could be an effective pain indicator, warranting further research to explore its potential as a biomarker in pain assessment.
Rubella virus vaccine-induced granulomas: a case in children with ataxia-telangiectasia.
Dermatol Reports
November 2024
Dermatology Department, Caen University Hospital, Caen.
Ataxia telangiectasia (AT) is a rare autosomal recessive primary immunodeficiency disorder (PID) resulting from a mutation in the ATM gene involved in DNA repair. We describe the case of a young girl with cutaneous granulomas that developed after childhood vaccinations. Immunohistochemistry revealed granulomas induced by the rubella virus vaccine.
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