Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in the United States and has only recently achieved a 5-yr survival rate of 10%. This dismal prognosis reflects the remarkable capacity of PDAC to effectively adapt to and resist therapeutic intervention. In this review, we discuss recent advances in our understanding of the biological underpinnings of PDAC and their implications as targetable vulnerabilities in this highly lethal disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8247606 | PMC |
| http://dx.doi.org/10.1101/gad.348523.121 | DOI Listing |
Publication Analysis
Top Keywords
biological underpinnings
8
underpinnings therapeutic
4
therapeutic resistance
4
resistance pancreatic
4
pancreatic cancer
4
cancer pancreatic
4
pancreatic ductal
4
ductal adenocarcinoma
4
adenocarcinoma pdac
4
pdac leading
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!