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Safety and efficacy of PD-1 inhibitor (sintilimab) combined with transarterial chemoembolization as the initial treatment in patients with intermediate-stage hepatocellular carcinoma beyond up-to-seven criteria.
J Immunother Cancer
January 2025
Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China
Background: Numerous studies have demonstrated limited survival benefits of transarterial chemoembolization (TACE) alone in the treatment of intermediate-stage hepatocellular carcinoma (HCC) beyond up-to-seven criteria. The advent of immunotherapy, particularly immune checkpoint inhibitors (ICIs), has opened new avenues for HCC treatment. However, TACE combined with ICIs has not been investigated for patients with intermediate-stage HCC beyond the up-to-seven criteria.
View Article and Find Full Text PDFInvestigating Endocrine Causes in Fluid Non-responsive Hypotension: An Interesting Case of a Pituitary Macroadenoma.
Cureus
December 2024
Internal Medicine, Max Smart Super Speciality Hospital, New Delhi, IND.
In this case, the message is conveyed that after ruling out sinister causes of hypotension, endocrine causes should also be considered, particularly in the light of a relatively long history, absence of any sepsis and organ dysfunction, preserved urine output, euvolemic status, and with no significant response to intravenous fluid. In our case, a patient with hypotension with relatively stable other clinical parameters has been evaluated to reveal pituitary macroadenoma as an underlying diagnosis.
View Article and Find Full Text PDFPositive association between chronic hepatitis B virus infection and anemia in pregnancy in Southern China.
Sci Rep
January 2025
Hainan Women and Children's Medical Center, Haikou, 571199, Hainan, China.
This observational investigation aimed to explore potential risk factors for anemia in pregnancy. Firstly, a cross-sectional study was conducted, encompassing a review of clinical data of 43,201 pregnant women admitted to the Hainan Women and Children's Medical Center between January 2017 and December 2020. Comparison between women with and without anemia in pregnancy revealed significant differences between the two groups concerning age, gestational diabetes, hypothyroidism, hyperthyroidism, chronic hepatitis B virus infection, syphilis infection, and human immunodeficiency virus infection.
View Article and Find Full Text PDFPituitary stalk interruption syndrome with coexistent focal cortical dysplasia in a young boy.
BMJ Case Rep
January 2025
Paediatrics, Bahrain Defence Force Royal Medical Services, Riffa, Bahrain.
This case report provides details of the first documented case of pituitary stalk interruption syndrome (PSIS) with coexistent focal cortical dysplasia (FCD) in a young boy. The child's initial presentation was an afebrile, generalised tonic-clonic seizure associated with postictal drowsiness. During his first episode, the physical examination revealed a short, obese child with a micropenis and left cryptorchidism.
View Article and Find Full Text PDFImpact of endocrine disorders associated with cleft lip and palate.
Turk J Pediatr
December 2024
Department of Plastic Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Background: Any impediment to the development of midline structures i.e. hypothalamus, pituitary and oral cavity may cause anatomical and functional issues.
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