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REM sleep behaviour disorder (RBD): Personal perspectives and research priorities.
J Sleep Res
May 2024
Minnesota Regional Sleep Disorders Center, Department of Psychiatry, Hennepin County Medical Center and University of Minnesota Medical School, Minneapolis, Minnesota, USA.
The formal identification and naming of rapid eye movement (REM) sleep behaviour disorder (RBD) in 1985-1987 is described; the historical background of RBD from 1966 to 1985 is briefly discussed; and RBD milestones are presented. Current knowledge on RBD is identified with reference to recent comprehensive reviews, allowing for a focus on research priorities for RBD: factors and predictors of neurodegenerative phenoconversion from isolated RBD and patient enrolment in neuroprotective trials; isolated RBD clinical research cohorts; epidemiology of RBD; traumatic brain injury, post-traumatic stress disorder, RBD and neurodegeneration; depression, RBD and synucleinopathy; evolution of prodromal RBD to neurodegeneration; gut microbiome dysbiosis and colonic synuclein histopathology in isolated RBD; other alpha-synuclein research in isolated RBD; narcolepsy-RBD; dreams and nightmares in RBD; phasic REM sleep in isolated RBD; RBD, periodic limb movements, periodic limb movement disorder pseudo-RBD; other neurophysiology research in RBD; cardiac scintigraphy (I-MIBG) in isolated RBD; brain magnetic resonance imaging biomarkers in isolated RBD; microRNAs as biomarkers in isolated RBD; actigraphic, other automated digital monitoring and machine learning research in RBD; prognostic counselling and ethical considerations in isolated RBD; and REM sleep basic science research. RBD research is flourishing, and is strategically situated at an ever-expanding crossroads of clinical (sleep) medicine, neurology, psychiatry and neuroscience.
View Article and Find Full Text PDFExceptionally high levels of total mercury in deep-sea sharks of the Southeastern Mediterranean sea over the last ∼ 40 years.
Environ Int
May 2024
Israel Oceanographic and Limnological Research, National Institute of Oceanography, Haifa 310800, Israel. Electronic address:
Deep-sea habitats are currently recognized as a hot spot for mercury (Hg) accumulation from anthropogenic sources, resulting in elevated concentrations of total mercury (THg) in deep-sea megafauna. Among them, deep-sea sharks (Class Chondrichthyes) are characterized by high trophic position and extended longevity and are, therefore, at high risk for mercury contamination. Despite this, sharks are overexploited by fishing activity in increasingly deeper water, worldwide, imposing health risks to human consumption.
View Article and Find Full Text PDFS100A1 and S100B: Calcium Sensors at the Cross-Roads of Multiple Chondrogenic Pathways.
J Cell Physiol
August 2017
Osteoarticular Research Group, Department of Clinical Research, University of Bern, Bern, Switzerland.
The S100 protein family comprises more than 20 members of small calcium binding proteins operating as Ca2 +-activated switches that interact and modulate the activity of a large number of targets. S100A1 and S100B, two members of this family, have been recently associated with the differentiation status of human articular chondrocytes. Both proteins are homogeneously expressed in all cartilage zones, their expression decreases during chondrocyte dedifferentiation, and can be induced under conditions promoting redifferentiation.
View Article and Find Full Text PDFThe article draws on sociological research conducted in the early 2000, about the training of French nurses. The author shows the transformation of a model of work and training of caring professions. The model that was traditionally focused on curative dimensions evolves into an organization that requires articulating both care and cure dimensions.
View Article and Find Full Text PDFThe molecular pathology of beta-thalassemia in Turkey: the Boğaziçi university experience.
Hemoglobin
July 2007
Department of Molecular Biology and Genetics, Neurodegeneration Research Laboratory, Boğaziçi University, Istanbul, Turkey.
The thalassemias are a diverse group of hemoglobin (Hb) disorders characterized by a reduced synthesis of the globin chains of Hb. Today, more than 200 mutations, affecting different levels of beta-globin gene expression, by a variety of mechanisms, are known to result in a beta-thalassemia (thal) phenotype. According to recent findings, the multilayered complexity in the phenotype of beta-thal is the result not only of marked molecular heterogeneity at the beta-globin locus, but at the level of several other genes as well.
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