AI Article Synopsis
- Dogs in Korea with hyperadrenocorticism often require higher doses of trilostane than those recommended elsewhere, possibly due to local compounding practices.
- An analysis was conducted on 44 medication packets for trilostane, comparing manually filled vs. semi-automatically filled packets for accuracy.
- Results showed that only 40.9% of packets contained acceptable trilostane levels, indicating that compounding inconsistencies might affect treatment effectiveness for dogs.
Article Abstract
Background: Dogs treated for naturally occurring hyperadrenocorticism (NOH) in Korea often appear to require higher doses of trilostane than recommended by authors in the United States, Europe, or the United Kingdom. This phenomenon may be related to compounding trilostane into packets, which is a common practice among veterinary clinics in Korea.
Objective: Analyze packets filled by hand and others filled using a semi-automatic packing device for accuracy of trilostane strength.
Animals: Medication packets prepared for 3 dogs with preexisting prescriptions for NOH were analyzed.
Method: A trilostane assay was developed for analysis. Trilostane (Vetoryl) capsules were used as clinical controls. Forty-four medication packets containing trilostane (Vetoryl), prepared by 3 clinicians for 3 dogs with NOH were analyzed.
Results: Of 44 trilostane-containing packets, only 40.9% (18 packets) had acceptable strength of trilostane.
Conclusions And Clinical Importance: Clinicians should be aware that compounding trilostane into packets fails to consistently provide measured amounts of trilostane, potentially interfering with response to treatment for NOH in dogs.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8295693 | PMC |
| http://dx.doi.org/10.1111/jvim.16197 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!