Cell cytotoxicity neutralization assay (CCNA) is considered to be a gold standard to diagnose infections. We performed CCNA on 77 consecutive admission screening rectal swabs from asymptomatic toxigenic carriers. Thirty-nine percent of specimens from asymptomatic carriers were positive. Thus, CCNA specificity may be lower than previously thought.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186239PMC
http://dx.doi.org/10.1093/ofid/ofab209DOI Listing

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