AI Article Synopsis
- Primary hyperaldosteronism (PA) affects 5-10% of patients with hypertension but is not typically linked to nephrocalcinosis, which is defined by kidney calcification.
- The primary causes of nephrocalcinosis include hyperparathyroidism, distal renal tubular acidosis, and medullary sponge kidney, and these were ruled out in all three cases discussed in the report.
- The study suggests that PA should be considered as a potential cause of medullary nephrocalcinosis in patients with difficult-to-control hypertension after excluding the common causes.
Article Abstract
Primary hyperaldosteronism (PA) is a common disease with a prevalence of 5-10% in unselected patients with hypertension. Medullary nephrocalcinosis is a radiological diagnosis and refers to diffuse calcification in the renal parenchyma. The three commonest causes of nephrocalcinosis are hyperparathyroidism, distal renal tubular acidosis, and medullary sponge kidney. PA is not a recognized cause of nephrocalcinosis. There are a few case reports linking PA with nephrocalcinosis published till date. In this case series, we report three cases where PA was possibly associated with medullary nephrocalcinosis. In all three cases, the common causes of nephrocalcinosis were excluded by careful clinical history, biochemical evaluation, and radiological findings. We conclude and emphasize that a diagnosis of PA as an etiology of medullary nephrocalcinosis should be sought after common causes have been excluded, at least in those with hypertension that is difficult to control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8179970 | PMC |
| http://dx.doi.org/10.5001/omj.2021.32 | DOI Listing |
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