Streptogramins are antibiotics produced by several species of bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative, fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural group A streptogramins and compare these routes to other reported syntheses.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186492 | PMC |
http://dx.doi.org/10.1055/a-1293-9655 | DOI Listing |
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