Modular synthesis of streptogramin antibiotics.

Synlett

Department of Pharmaceutical Chemistry and Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94158, United States.

Published: April 2021

Streptogramins are antibiotics produced by several species of bacteria that are used in both human and veterinary medicine. Group A streptogramins comprise 23-membered macrocyclic polyketide/nonribosomal peptide hybrids for which several innovative, fully synthetic routes have been developed. Herein we describe in detail our scalable routes to natural group A streptogramins and compare these routes to other reported syntheses.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8186492PMC
http://dx.doi.org/10.1055/a-1293-9655DOI Listing

Publication Analysis

Top Keywords

group streptogramins
8
modular synthesis
4
synthesis streptogramin
4
streptogramin antibiotics
4
antibiotics streptogramins
4
streptogramins antibiotics
4
antibiotics produced
4
produced species
4
species bacteria
4
bacteria human
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!