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Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material.
J Vis Exp
December 2024
School of Engineering and Materials Science, Queen Mary University of London.
Article Synopsis
- The study evaluates the fracture strength of 1 mm-thick CAD/CAM occlusal veneers made from lithium disilicate (LD) and resin nanoceramics (RNC) to assess their viability in dental restoration.
- Using a novel testing protocol, the RNC group demonstrated a significantly higher load-bearing capacity compared to the LD group, indicating better durability under stress.
- Both materials experienced similar crack patterns during testing, emphasizing the importance of understanding mechanical properties for ensuring the longevity of dental restorations.
Optimized protocol for culturing menstrual blood-derived MSCs for combination with oncolytic adenoviruses in cancer treatment.
Mol Ther Oncol
December 2024
Cancer Immunotherapy Group, Oncobell and iProCURE programs, IDIBELL-Institut Català d'Oncologia, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Oncolytic viruses (OVs) are a promising therapeutic approach for cancer, although their systemic administration faces significant challenges. Mesenchymal stem cells have emerged as potential carriers to overcome these obstacles due to their tumor-tropic properties. This study investigates the use of menstrual blood-derived mesenchymal stem cells (MenSCs) as carriers for OVs in cancer therapy, focusing on enhancing their efficacy through different culture conditions.
View Article and Find Full Text PDFApproaches to regenerative endodontic therapy in necrotic human teeth with complete root formation: a systematic review.
Clin Oral Investig
January 2025
Graduate Program in Dentistry, ULBRA, Avenue. Farroupilha 8001, Zip Code, Canoas, 92425-900, Brazil.
Introduction: Regenerative endodontic procedures (REPs) aim to replace damaged dental structures and regenerate the dentin-pulp complex. Initially focused on teeth with incomplete root formation, recent research shows promise for necrotic teeth with complete root formation.
Methodology: This review, following PRISMA guidelines and registered in PROSPERO, included clinical studies on regenerative endodontic therapy in necrotic human teeth with complete root formation.
Effect of flood on the cutaneous leishmaniasis incidence in northeast of Iran: an interrupted time series study.
BMC Infect Dis
January 2025
Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran.
Introduction: Cutaneous Leishmaniasis (CL) is a zoonosis infection which is endemic in more than 100 countries in Asia, Africa, Europe and America. It was estimated that nearly 20 thousand of new cases are reported in Iran annually. This study aimed to investigate the impact of floods on the incidence of leishmaniasis in Golestan province (northeast of Iran) over nine years, from 2015 to 2023.
View Article and Find Full Text PDFEDENT1FI Master Protocol for screening of presymptomatic early-stage type 1 diabetes in children and adolescents.
BMJ Open
January 2025
Institute of Diabetes Research, Helmholtz Munich German Research Center for Environmental Health, Munich, Germany
Introduction: The identification of type 1 diabetes at an early presymptomatic stage has clinical benefits. These include a reduced risk of diabetic ketoacidosis (DKA) at the clinical manifestation of the disease and a significant reduction in clinical symptoms. The European action for the Diagnosis of Early Non-clinical Type 1 diabetes For disease Interception (EDENT1FI) represents a pioneering effort to advance early detection of type 1 diabetes through public health screening.
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