Background: Cognitive impairment is one of the common features of multiple sclerosis (MS). Despite high prevalence, cognitive decline is often overlooked by neurologists. The Brief International Cognitive Assessment for MS (BICAMS) was therefore introduced by the international expert committee as a brief and effective tool for the assessment and monitoring of cognitive functions in patients with MS. The validity and reliability of BICAMS have been demonstrated in many countries. Our aim was to validate the BICAMS in Georgian patients with MS.
Methods: A total of 68 patients with MS and 68 matched controls were assessed by the Georgian-language BICAMS. All healthy controls and seven patients were re-evaluated with identical tests to assess retest reliability.
Results: In comparison to healthy controls, patients with MS performed significantly worse on all tests in the assessment battery. Test-retest reliability measures were good for all tests. The prevalence of cognitive impairment in patients with MS was 43%.
Conclusion: The Georgian-language BICAMS is a reliable and valid battery for the assessment of cognitive function in patients with MS.
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http://dx.doi.org/10.1186/s12883-021-02249-x | DOI Listing |
CJEM
January 2025
Department of Emergency Medicine and Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Objectives: POCUS is a core emergency medicine skill and mainstay of early pregnancy assessment. The ultrasound competency assessment tool was developed as an entrustment-based assessment tool for use by content experts evaluating trainees performing multiple POCUS study types. The objective of this study was to evaluate the scoring and extrapolation inferences of the tool within Kane's validity framework when used to assess trainees performing an early pregnancy POCUS.
View Article and Find Full Text PDFJ Cancer Educ
January 2025
Department of Surgery, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
Cancer is a major health challenge globally and in Sri Lanka. Providing comprehensive information to patients is crucial for improving treatment outcomes and patient satisfaction, supported by evidence of its effectiveness in managing cancer pain. EORTC QLQ-INFO25, an information module developed by the European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group, is aimed at assessing cancer patients' perception of information received during different phases of care.
View Article and Find Full Text PDFMikrochim Acta
January 2025
Applied Science Department, The NorthCap University, 122017, Gurugram, Haryana, India.
For the first time, a TiCT-MXene and poly (3, 4-ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT: PSS) composite-modified electrode has been developed for electrochemical detection of the bilirubin (BR) by molecularly imprinted ortho-phenylenediamine (o-PD). BR is a biomarker for liver-related diseases. High levels of BR imply liver dysfunction; hence, its exact and rapid measurement is indispensable to its immediate diagnosis and treatment.
View Article and Find Full Text PDFEur Radiol
January 2025
Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Objectives: To explore the reproducibility of the 1.5-T MR imaging (MRI)-based R2* method in measuring the liver iron concentration (LIC) across different MRI scanners, scan parameters, and postprocessing techniques.
Materials And Methods: We performed a systematic search of the PubMed, Embase, Medline, Cochrane Library, and Web of Science databases and identified studies that used the 1.
Alzheimers Dement
December 2024
Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Although pharmacokinetics and pharmacodynamics of biotherapeutics are commonly studied through ELISAs; however, the extremely strong binding of modern antibody-based therapeutics result in background, inability of secondary antibody binding, and nonlinear response curves. The selectivity and specificity imparted through the use of liquid chromatography-targeted mass spectrometry (LC-MS/MS) allows for absolute quantitation of chosen peptides. For MODEL-AD, here we present a high-throughput workflow for absolute quantification of chimeric aducanumab from cortex and plasma of 5XFAD mice.
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