AI Article Synopsis
- - The study investigates how skin aging affects the structure and function of the skin barrier by comparing individuals under 24 and over 70 years old, focusing on molecular and biophysical changes.
- - Findings indicate that older adults have a reduced lipid-to-protein ratio in the skin's outer layer, which affects hydration levels and reduces water loss, despite similar surface water content across age groups.
- - Mechanical properties of the skin, like elasticity and resistance to fatigue, decline with age, and these changes are linked to the presence of bound water in the skin layers.
Article Abstract
Skin aging is a multifactorial phenomenon that involves alterations at the molecular, cellular and tissue levels. Our aim was to carry out a multiparametric biophysical and Raman characterization of skin barrier between individuals of different age groups (<24 and >70 years old). Our results showed a significant decrease of lipids to proteins ratio overall the thickness of the stratum corneum and higher lateral packing in the outer part of the SC for elderly. This can explain the decrease in trans epidermal water loss measured values rather than only SC thickening. Both age groups showed similar water content at SC surface while elderly presented higher water content in deep SC and viable epidermis. Mechanical measurements showed a decrease in the elasticity and an increase in the fatigability with age and were correlated with partially bound water. Highest correlation and anti-correlation values were observed for the deepest part of the SC and the viable epidermis.
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| http://dx.doi.org/10.1002/jbio.202100107 | DOI Listing |
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