ABA renewal was assessed by decreasing response rates by means of extinction or a 12-s delay of reinforcement in one experiment with rats. In a first phase, rats were trained to lever press for water in Context A. Rats were exposed to a second phase in Context B, where lever-pressing decreased for all rats; for one group of rats, lever-pressing decreased by means of extinction, while lever-pressing decreased by means of a 12-s delay for the other group. During a third phase, both groups were once again exposed to Context A with no reinforcer deliveries for lever-pressing. Once rats were exposed to the latter phase, renewal was observed for both groups. Results suggest that delay of reinforcement can be used as an alternative procedure to help reduce behavior and mitigate relapse.
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http://dx.doi.org/10.1016/j.beproc.2021.104440 | DOI Listing |
Hum Brain Mapp
February 2025
Department of Neurology, Centre for Leading Medicine and Advanced Technologies of IHM, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Apathy is a common neuropsychiatric symptom following stroke, characterized by reduced goal-directed behavior. The reward decision network (RDN), which plays a crucial role in regulating goal-directed behaviors, is closely associated with apathy. However, the relationship between poststroke apathy (PSA) and RDN dysfunction remains unclear due to apathy heterogeneity, the confounding effect of depression and individual variability in lesion impacts.
View Article and Find Full Text PDFJ Pharmacol Sci
February 2025
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, 46-29 Yoshida-Shimoadachi-cho, Sakyo-ku, Kyoto, 606-8501, Japan; Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Japan; Project for Neural Networks, Drug Innovation Center, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, 565-0871, Japan. Electronic address:
Major depressive disorder (MDD) is among the most common mental disorders worldwide and is characterized by dysregulated reward processing associated with anhedonia. Selective serotonin reuptake inhibitors (SSRIs) are the first-line treatment for MDD; however, their onset of action is delayed. Recent reports have shown that serotonin neurons in the dorsal raphe nucleus (DRN) are activated by rewards and play a vital role in reward processing.
View Article and Find Full Text PDFLearn Mem
January 2025
Department of Psychology, Arizona State University, Tempe, Arizona 85287, USA
Chronic stress typically leads to deficits in fear extinction. However, when a delay occurs from the end of chronic stress and the start of fear conditioning (a "recovery"), rats show improved context-cue discrimination, compared to recently stressed rats or nonstressed rats. The infralimbic cortex (IL) is important for fear extinction and undergoes neuronal remodeling after chronic stress ends, which could drive improved context-cue discrimination.
View Article and Find Full Text PDFIntroduction: Simulation has become an integral part of health care education curricula that is used to teach a variety of topics, from emergency situations to physical diagnoses. Without further reinforcement, the skills learned through the simulation are subject to deterioration over time. Rapid Cycle Deliberate Practice (RCDP) is a teaching method that was developed to resist this deterioration and achieve mastery of skills.
View Article and Find Full Text PDFBMJ Open
January 2025
Surveillance and Health Services Research, American Cancer Society, Atlanta, Georgia, USA.
Objective: Cervical cancer remains the most diagnosed and deadly cancer among women in low and middle income countries, including Ethiopia, although it can be controlled if detected and treated early. However, research on contextual barriers to early diagnosis and treatment of cervical cancer is limited in Ethiopia. This study aimed to describe the lived experience of the patients and to explore the barriers to early diagnosis and treatment of cervical cancer.
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