Handwritten signature verification is a challenging task because signatures of a writer may be skillfully imitated by a forger. As skilled forgeries are generally difficult to acquire for training, in this paper, we propose a deep learning-based dynamic signature verification framework, SynSig2Vec, to address the skilled forgery attack without training with any skilled forgeries. Specifically, SynSig2Vec consists of a novel learning-by-synthesis method for training and a 1D convolutional neural network model, called Sig2Vec, for signature representation extraction. The learning-by-synthesis method first applies the Sigma Lognormal model to synthesize signatures with different distortion levels for genuine template signatures, and then learns to rank these synthesized samples in a learnable representation space based on average precision optimization. The representation space is achieved by the proposed Sig2Vec model, which is designed to extract fixed-length representations from dynamic signatures of arbitrary lengths. Through this training method, the Sig2Vec model can extract extremely effective signature representations for verification. Our SynSig2Vec framework requires only genuine signatures for training, yet achieves state-of-the-art performance on the largest dynamic signature database to date, DeepSignDB, in both skilled forgery and random forgery scenarios. Source codes of SynSig2Vec will be available at https://github.com/LaiSongxuan/SynSig2Vec.
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http://dx.doi.org/10.1109/TPAMI.2021.3087619 | DOI Listing |
Sci Adv
March 2025
Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
U6 small nuclear RNA (U6 snRNA), a critical spliceosome component primarily found in the nucleus, plays a vital role in RNA splicing. Our previous study, using the simian immunodeficiency virus (SIV) macaque model, revealed an increase of U6 snRNA in plasma extracellular vesicles (EVs) in acute retroviral infection. Given the limited understanding of U6 snRNA dynamics across cells and EVs, particularly in SIV infection, this research explores U6 snRNA trafficking and its association with splicing proteins in the nucleus, cytoplasm, and EVs.
View Article and Find Full Text PDFPLoS One
March 2025
Department of Physics, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
DNA polymerase β, a member of the X-family of DNA polymerases, undergoes complex regulations both in vitro and in vivo through various posttranslational modifications, including phosphorylation and methylation. The impact of these modifications varies depending on the specific amino acid undergoing alterations. In vitro, methylation of DNA polymerase β with the enzyme protein arginine methyltransferase 6 (PRMT6) at R83 and R152 enhances polymerase activity by improving DNA binding and processivity.
View Article and Find Full Text PDFNucleic Acids Res
February 2025
Institut de Biologie de l'Ecole Normale Supérieure (IBENS), Ecole normale supérieure, CNRS, INSERM, PSL Research University, 46 rue d'Ulm, 75005 Paris, France.
Upf1 RNA helicase is a pivotal factor in the conserved nonsense-mediated mRNA decay (NMD) process. Upf1 is responsible for coordinating the recognition of premature termination codons (PTCs) in a translation-dependent manner and subsequently triggering mRNA degradation. Multiple factors assist Upf1 during these two consecutive steps.
View Article and Find Full Text PDFCurrently, static fluorescent anti-counterfeiting technology struggles to cope with the increasingly sophisticated counterfeiting techniques, making the dynamic multimode regulation scheme an urgent necessity. Herein, Sm3+ mono-/co-doped LiTaO3 (LTO) phosphors are prepared by high temperature solid state method. Under 254 nm excitation, the emission chromaticity of LTO: Tb3+, Sm3+ is modulated from green to yellow by increasing Sm3+ content due to Tb3+ → Sm3+ energy transfer.
View Article and Find Full Text PDFiScience
March 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.
Brain endothelial cells (BECs) play an important role in maintaining central nervous system (CNS) homeostasis through blood-brain barrier (BBB) functions. BECs express low baseline levels of adhesion receptors, which limits entry of leukocytes. However, the molecular mediators governing this phenotype remain mostly unclear.
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