Invited for the cover of this issue is the group of Timo Repo at the University of Helsinki. The image depicts a ligand-exchange reaction as a battle between hummingbirds and golden birds, which represent two different thiol ligands. Read the full text of the article at 10.1002/chem.202101028.
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| http://dx.doi.org/10.1002/chem.202101714 | DOI Listing |
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Tannic acid coordination assembly enhances the interfacial properties of salted egg white gel particles.
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Cooperative Innovation Center of Industrial Fermentation, Ministry of education & Hubei province, National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, China. Electronic address:
Tannic acid (TA) has attracted the attention of researchers as a promising organic ligand capable of forming metal-organic coordination networks with various metal ions at interfaces to impact surface properties. In this study, we innovatively reported a self-assembly method for surface decoration by depositing TA/Fe coatings on the surface of desalted duck egg white nanoparticles (DEWN), further studying the oil/water interfacial properties of the modified particles. The results showed that the ratio and concentration of TA to Fe could modulate interfacial properties.
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Catechol-O-methyltransferase (COMT, EC 2.1.1.
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Heidelberg University, Medical Faculty Heidelberg, Department of Dermatology and National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and University Hospital Heidelberg, Heidelberg, Germany.
Immune checkpoint blockers have substantially improved prognosis of melanoma patients, nevertheless, resistance remains a significant problem. Here, intrinsic and extrinsic factors in the tumor microenvironment are discussed, including the expression of alternative immune checkpoints such as lymphocyte activation gene 3 (LAG-3) and T-cell immunoglobulin and mucin domain-containing protein 3 (TIM-3). While most studies focus on immune cell expression of these proteins, we investigated their melanoma cell intrinsic expression by immunohistochemistry in melanoma metastases of 60 patients treated with anti-programmed cell death protein 1 (PD-1) and/or anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) therapy, and correlated it with the expression of potential ligands, RNA sequencing data and clinical outcome.
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The development of high activity catalysts is crucial for improving industrial efficiency and mitigating environmental pollution. Polyisocyanides, with their pendant groups capable of forming ordered adjacent structures, offer a promising framework for designing cooperative catalysts that mimic the functionality of bimetallic centers. This unique structural arrangement is anticipated to significantly enhance catalytic activity in cooperative reactions.
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Biosci Rep
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Multicentre redox proteins participate in diverse metabolic processes, such as redox shuttling, multielectron catalysis, or long-distance electron conduction. The detail in which these processes can be analysed depends on the capacity of experimental methods to discriminate the multiple microstates that can be populated while the protein changes from the fully reduced to the fully oxidized state. The population of each state depends on the redox potential of the individual centres and on the magnitude of the interactions between the individual redox centres with their neighbours.
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