AI Article Synopsis

  • The study examines the relationship between different obesity phenotypes and bone health in an elderly population, focusing on osteoporosis and bone density.
  • Using data from the Bushehr Elderly Health Program, participants were categorized into four obesity groups based on metabolic health status to analyze their risk of osteoporosis and bone quality.
  • Findings indicate that regardless of obesity phenotype, individuals with obesity generally exhibit lower bone quality, revealing the need for further investigation into how metabolic factors influence bone health.

Article Abstract

Introduction: Obesity and osteoporosis are health problems with high impact on the morbidity and mortality rate. While the association between BMI and bone density is known, the combined effects of obesity and metabolic components on bone health have not yet been revealed. The objectives of this study were to determine the association between bone health and different phenotypes of obesity in an elderly population.

Methods: This cross-sectional study was conducted on the data collected in the Bushehr Elderly Health Program (BEHP). The participants were classified in four groups based on the metabolic phenotypes of obesity (metabolic healthy obese (MHO), metabolic non-healthy non-obese (MNHNO), metabolic non-healthy obese (MNHO), and metabolic healthy non-obese (MHNO)). The association between osteoporosis and TBS and the metabolic phenotypes of obesity were assessed using multiple variable logistic regression models.

Results: Totally, 2378 people (1227 women) were considered for analyses. The prevalence of MHNO, MHO, MNHNO, and MNHO were 902 (39.9%), 138 (6.1%), 758 (33.5%), and 464 (20.5%), respectively. In the multivariate logistic regression models, those with MHO (OR 0.22; 95% CI 0.12-0.36), MNHNO (OR 0.52; 95% CI 0.4-0.66), and MNHO phenotypes (OR 0.22; 95% CI 0.16-0.3) had a significantly lower risk of osteoporosis. Likewise, those having MHO (OR 2.38; 95% CI 1.51-3.76), MNHNO (OR 1.49; 95% CI 1.11-2), and MNHO (OR 2.50; 95% CI 1.82-3.42) phenotypes were found to had higher risk of low bone quality as confirmed by TBS.

Conclusions: The obese subjects have lower bone quality, regardless of their obesity phenotype.

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http://dx.doi.org/10.1007/s11657-021-00953-2DOI Listing

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