AI Article Synopsis
- Oral cancer (OC) is a complex disease influenced by factors like tobacco, alcohol, and HPV, and has a low survival rate after traditional treatments.
- Natural products have shown promising anti-tumor and chemopreventive properties, making them potential candidates for OC treatment.
- Many of these natural compounds can induce apoptosis and inhibit growth and spread of cancer cells, suggesting they may play a key role in future prevention and therapy for OC.
Article Abstract
Oral cancer (OC) is a multifactorial disease caused by isolated or combined risk factors related to tobacco, alcohol consumption, and human papillomavirus infection. It is an aggressive pathology with a low five-year survival rate after surgery, chemotherapy, and/or radiotherapy, frequently associated with severe side effects. Drugs with the highest anti-tumor effect are obtained from natural products with diverse biological and molecular activities and potential chemopreventive and anticancer properties. This review summarizes the natural products reported to have the chemopreventive and anti-tumor potential for OC treatment, showing that several of these compounds are promising candidates as chemopreventive agents, and those with the highest anti-tumor potential induce apoptosis and inhibit proliferation and metastasis-related processes. For this reason, natural products have the potential to be important preventive and therapeutic options for OC in the future.
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| http://dx.doi.org/10.1080/01635581.2021.1931698 | DOI Listing |
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