AI Article Synopsis
- Wearable devices like smart watches use green LEDs for monitoring health through photoplethysmography, and researchers have developed a new system called Glow Control that can trigger gene expression with light.
- Glow Control utilizes a combination of engineered proteins to activate a gene's expression when illuminated, enabling remote control via devices like the Apple Watch.
- This innovative approach has shown promise in treating type-2 diabetes by enabling implanted cells to produce a hormone on demand, ultimately linking personalized medicine with technology for improved healthcare solutions.
Article Abstract
Wearable smart electronic devices, such as smart watches, are generally equipped with green-light-emitting diodes, which are used for photoplethysmography to monitor a panoply of physical health parameters. Here, we present a traceless, green-light-operated, smart-watch-controlled mammalian gene switch (Glow Control), composed of an engineered membrane-tethered green-light-sensitive cobalamin-binding domain of Thermus thermophilus (TtCBD) CarH protein in combination with a synthetic cytosolic TtCBD-transactivator fusion protein, which manage translocation of TtCBD-transactivator into the nucleus to trigger expression of transgenes upon illumination. We show that Apple-Watch-programmed percutaneous remote control of implanted Glow-controlled engineered human cells can effectively treat experimental type-2 diabetes by producing and releasing human glucagon-like peptide-1 on demand. Directly interfacing wearable smart electronic devices with therapeutic gene expression will advance next-generation personalized therapies by linking biopharmaceutical interventions to the internet of things.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8184832 | PMC |
| http://dx.doi.org/10.1038/s41467-021-23572-4 | DOI Listing |
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