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Interaction of the atypical neuroleptic clozapine with 5-HT3 receptors in the cerebral cortex and superior cervical ganglion of the rat.
Eur J Pharmacol
July 1990
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex, U.K.
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several other antipsychotic agents, including fluphenazine, alpha-flupenthixol, haloperidol, spiperone and (-)-sulpiride were essentially inactive.
View Article and Find Full Text PDF[3H]quaternised ICS 205-930 labels 5-HT3 receptor binding sites in rat brain.
Eur J Pharmacol
May 1988
Department of Biochemistry, Merck Sharp and Dohme Research Laboratories, Harlow, Essex, U.K.
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