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| http://dx.doi.org/10.18632/aging.203177 | DOI Listing |
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Silymarin nanoparticles counteract cognitive impairment induced by doxorubicin and cyclophosphamide in rats; Insights into mitochondrial dysfunction and Nrf-2/HO-1 axis.
Eur J Pharmacol
December 2024
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, 11566, Cairo, Egypt.
Most cancer patients suffer cognitive impairment following chemotherapy, recognized as "chemobrain". Principally, doxorubicin and cyclophosphamide are frequently utilized conjointly for the treatment of several kinds of tumors. Silymarin was reported to possess anti-inflammatory, antioxidant, and neuroprotective impacts.
View Article and Find Full Text PDFRejuvenating aged osteoprogenitors for bone repair.
Elife
December 2024
Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland.
Aging is marked by a decline in tissue regeneration, posing significant challenges to an increasingly older population. Here, we investigate age-related impairments in calvarial bone healing and introduce a novel two-part rejuvenation strategy to restore youthful repair. We demonstrate that aging negatively impacts the calvarial bone structure and its osteogenic tissues, diminishing osteoprogenitor number and function and severely impairing bone formation.
View Article and Find Full Text PDFDepression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration.
Biol Res
November 2024
College of Pharmacy, Gachon University, #191, Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.
Background: Depression and memory loss are prevalent neurodegenerative disorders, with diabetic patients facing an elevated risk of brain dysfunction. Methylglyoxal (MGO) formation, which is heightened in diabetes owing to hyperglycemia and gut dysbiosis, may serve as a critical link between diabetes and brain diseases. Despite the high prevalence of MGO, the precise mechanisms underlying MGO-induced depression and memory loss remain unclear.
View Article and Find Full Text PDFAccidental Physical Trauma in Children and Youth with Special Health Care Needs: A Scoping Review.
Acad Pediatr
October 2024
Department of Pediatrics (S Ribeiro, A Zrik, V Janjua, J Assioun, and DZ Kuo), Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY; Department of Pediatrics (V Janjua and DZ Kuo), University of Rochester School of Medicine and Dentistry, Rochester, NY.
Background: Children and youth with special health care needs (CYSHCN) may be at greater risk for accidental physical trauma. Interventions should be informed by the literature indicating incident characteristics and at-risk subpopulations.
Objective: To conduct a scoping review of accidental physical trauma in CYSHCN to characterize published literature and identify gaps.
The Effects of Variation in the GABA Receptor Gene on Anxious Depression are Mediated by the Functional Connectivity Between the Amygdala and Middle Frontal Gyrus.
Neuropsychiatr Dis Treat
September 2024
School of Biological Sciences and Medical Engineering, Southeast University, Nanjing, People's Republic of China.
Background: γ-aminobutyric acid (GABA) and its main receptor, the GABA receptor, are implicated in major depressive disorder (MDD). Anxious depression (AD) is deemed to be a primary subtype of MDD. The amygdala and the dorsolateral prefrontal cortex (DLPFC) are key brain regions involved in emotional regulation.
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