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| http://dx.doi.org/10.1002/pmrj.12612 | DOI Listing |
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Precise photorelease in living cells by high-viscosity activatable coumarin-based photocages.
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School of Biomedical Engineering, Shanghai Jiao Tong University Shanghai 200240 China
Intracellular viscosity is a critical microenvironmental factor in various biological systems, and its abnormal increase is closely linked to the progression of many diseases. Therefore, precisely controlling the release of bioactive molecules in high-viscosity regions is vital for understanding disease mechanisms and advancing their diagnosis and treatment. However, viscosity alone cannot directly trigger chemical reactions.
View Article and Find Full Text PDFAnalyzing the Effectiveness of Different Delivery Methods for Remineralization Agents in Pediatric Dental Health: A Systematic Review.
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College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, SAU.
Pediatric dental health is critically impacted by enamel demineralization and early-stage caries, with remineralization therapies playing a vital role in preventing progression. This systematic review evaluates the effectiveness of various delivery methods for remineralization agents in pediatric patients aged 3-15 years, focusing on varnishes, gels, foams, and sprays. Studies were included if they were randomized controlled trials (RCTs), cohort studies, or case-control studies involving pediatric patients with early-stage caries or enamel demineralization, while studies with non-pediatric populations, unrelated treatments, or significant methodological flaws were excluded.
View Article and Find Full Text PDFPlasmonic Nanoparticles for Photothermal Therapy: Benchmarking of Photothermal Properties and Modeling of Heating at Depth in Human Tissues.
J Phys Chem C Nanomater Interfaces
January 2025
Department of Physics and Astronomy, University of Exeter, Exeter EX4 4QL, U.K.
Many different types of nanoparticles have been developed for photothermal therapy (PTT), but directly comparing their efficacy as heaters and determining how they will perform when localized at depth in tissue remains complex. To choose the optimal nanoparticle for a desired hyperthermic therapy, it is vital to understand how efficiently different nanoparticles extinguish laser light and convert that energy to heat. In this paper, we apply photothermal mass conversion efficiency (η ) as a metric to compare nanoparticles of different shapes, sizes, and conversion efficiencies.
View Article and Find Full Text PDFThe high compliance of the urinary bladder during filling is essential for its proper function, enabling it to accommodate significant volumetric increases with minimal rise in transmural pressure. This study aimed to elucidate the physical mechanisms underlying this phenomenon by analyzing the ex vivo filling process in rat from a fully voided state to complete distension, without preconditioning, using three complementary imaging modalities. High-resolution micro-CT at 10.
View Article and Find Full Text PDFConcomitant motor responses facilitate the acquisition of multiple prior distributions in human coincidence timing.
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Graduate School of Integrated Science and Technology, Shizuoka University, Hamamatsu 432-8011, Japan.
The brain optimizes timing behaviour by acquiring a prior distribution of target timing and integrating it with sensory inputs. Real events have distinct temporal statistics (e.g.
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