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Metabolomics identifies plasma biomarkers of localized radiation injury.
Sci Rep
January 2025
Institut de Radioprotection et de Sureté Nucléaire (IRSN), PSE-SANTE/SERAMED/LRAcc, 31 av de la Division Leclerc, Fontenay-aux-Roses, 92260, France.
A radiological accident may result in the development of a local skin radiation injury (LRI) which may evolve, depending on the dose, from dry desquamation to deep ulceration and necrosis through unpredictable inflammatory waves. Therefore, early diagnosis of victims of LRI is crucial for improving medical care efficiency. This preclinical study aims to identify circulating metabolites as biomarkers associated with LRI using a C57BL/6J mouse model of hind limb irradiation.
View Article and Find Full Text PDFRadiofrequency Induced Time-Dependent Alterations in Gene Expression and Apoptosis in Glioblastoma Cell Line.
Bioelectromagnetics
January 2025
Department of Biophysics, Faculty of Medicine, Gazi University, Ankara, Turkey.
The widespread use of wireless communication technologies has increased human exposure to radiofrequency electromagnetic fields (RF-EMFs). Considering the brain's close proximity to mobile phones and its entirely electrical transmission network, it emerges as the organ most profoundly impacted by the RF field. This study aims to investigate the potential effects of RF radiation on cell viability, apoptosis, and gene expressions in glioblastoma cells (U118-MG) at different exposure times (1, 24, and 48 h).
View Article and Find Full Text PDFUltrasound-Mediated Piezoelectric Microneedles Regulating Macrophage Polarization and Remodeling Pathological Microenvironment for Lymphedema Improvement.
ACS Nano
January 2025
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China.
Lymphedema, a severe and complex inflammatory disease caused by lymphatic system insufficiency and impeded lymphatic drainage that causes an enormous physical and psychological burden on patients and may even lead to death, has long been a challenging issue in the medical field. Clinically, conventional approaches including surgical treatment and conservative treatment have been employed for lymphedema therapy, but their curative effect is still unsatisfactory because of high operational difficulty, high cost, and long-term reliance. In this study, a novel kind of piezoelectric microneedle driven by ultrasound (US) is proposed to regulate macrophage polarization and remodel the pathological inflammatory microenvironment in a noninvasive manner, thereby promoting lymphatic regeneration and improving lymphedema.
View Article and Find Full Text PDFCommon and specific gene regulatory programs in zebrafish caudal fin regeneration at single-cell resolution.
Genome Res
January 2025
Department of Genetics, Washington University School of Medicine, St. Louis, Missouri 63110, USA;
Following amputation, zebrafish regenerate their injured caudal fin through lineage-restricted reprogramming. Although previous studies have charted various genetic and epigenetic dimensions of this process, the intricate gene regulatory programs shared by, or unique to, different regenerating cell types remain underinvestigated. Here, we mapped the regulatory landscape of fin regeneration by applying paired snRNA-seq and snATAC-seq on uninjured and regenerating fins.
View Article and Find Full Text PDFThe incidence trends of papillary thyroid carcinoma in Belarus during the post-Chernobyl epoch.
Cancer Epidemiol
January 2025
Republican Scientific Centre for Radiation Medicine and Human Ecology, Illich, 290, Gomel 246040, Belarus.
Background: The increase of papillary thyroid cancer (PTC) rate among children who were exposed to post-Chernobyl 131-I release was reported only four years after the accident, first in Belarus where the heaviest fallout happened. The evolution of the occurrence of thyroid carcinoma based on the age-period-cohort analysis and the effects of age, period, and birth cohort on time trends aimed to reveal if post-Chernobyl follicular cells irradiation still has been impacting on incidence rate of papillary thyroid carcinoma nowadays.
Methods: The Belarusian Cancer Registry was used to identify patients with PTC diagnosed during the years 1980-2019.
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