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| http://dx.doi.org/10.1016/j.cnp.2021.04.002 | DOI Listing |
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Computational modelling of cardiac control following myocardial infarction using an in silico patient cohort.
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Daniel Baugh Institute for Functional Genomics and Computational Biology, Department of Pathology and Genomic Medicine, Thomas Jefferson University, Philadelphia, PA, USA.
Loss of cardiac physiological function following myocardial infarction (MI) is accompanied by neural adaptations in the baroreflex that are compensatory in the short term, but then become associated with long-term disease progression. One marker of these adaptations is decreased baroreflex sensitivity, a strong predictor of post-MI mortality. The relative contributions of cardiac remodelling and neural adaptation in the sensory, central brainstem and peripheral ganglionic loci to baroreflex sensitivity changes remain underexplored.
View Article and Find Full Text PDFSpinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration.
Cell Rep
December 2024
Department of Neuroscience Physiology and Pharmacology (NPP), University College London, Gower Street, WC1E 6BT London, UK. Electronic address:
Article Synopsis
- The study explores how neural circuits in mice adapt during early stages of progressive motoneuron degeneration, which helps maintain normal movement despite cell loss.
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Harvest of Vestibular End-Organs under Physiologic Conditions during Labyrinthectomy.
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Department of Otolaryngology - Head & Neck Surgery, Johns Hopkins University School of Medicine.
The living human inner ear is challenging to study because it is encased within dense otic capsule bone that limits access to biological tissue. Traditional temporal bone histopathology methods rely on lengthy, expensive decalcification protocols that take 9-10 months and reduce the types of tissue analysis possible due to RNA degradation. There is a critical need to develop methods to access fresh human inner ear tissue to better understand otologic diseases, such as Ménière's disease, at the cellular and molecular level.
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Department of Pharmacology and Physiology, Saint Louis University School of Medicine, 1402 South Grand Boulevard, Saint Louis, MO 63104.
Alterations in mitochondrial function are the linchpin in numerous disease states including in the development of chemotherapy-induced neuropathic pain (CIPN), a major dose-limiting toxicity of widely used chemotherapeutic cytotoxins. In CIPN, mitochondrial dysfunction is characterized by deficits in mitochondrial bioenergetics (e.g.
View Article and Find Full Text PDFRare internal hernia following pancreatoduodenectomy: A case report.
Int J Surg Case Rep
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Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Introduction: Pancreatoduodenectomy (PD) is a complex procedure with a high morbidity rate. Internal hernia following PD is a rare but potentially life-threatening complication. Herein, we describe a rare case of internal hernia after PD.
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