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| http://dx.doi.org/10.18632/oncoscience.537 | DOI Listing |
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The IncRNA SCIRT Promotes the Proliferative, Migratory, and Invasive Properties of Cervical Cancer Cells by Upregulating MMP-2/-9.
J Oncol
August 2022
Department of Obstetrics and Gynecology, Yancheng TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Yancheng, Jiangsu, China.
Objective: The morbidity and mortality of cervical cancer (CC) rank the fourth-most common among cancers in females, seriously threatening women's health and affecting their quality of life. However, the molecular mechanism of CC development remains poorly understood. This study investigates the role of lncRNA SCIRT in the development of CC.
View Article and Find Full Text PDFLong Noncoding RNA SCIRT Promotes HUVEC Angiogenesis via Stabilizing VEGFA mRNA Induced by Hypoxia.
Oxid Med Cell Longev
June 2022
Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.
Ischemia-reperfusion injury (IRI) is closely associated the abnormal expression of long noncoding RNAs (lncRNAs), especially for their regulatory roles in IRI-related angiogenesis. This study applied a hypoxia-reoxygenation (HR) cell model to simulate the IRI condition, as well as RNA sequencing and RNA pull-down experiments to reveal roles of the lncRNA and Stem Cell Inhibitory RNA Transcript (SCIRT), in endothelial angiogenesis. We found that SCIRT was increased under the HR condition and exhibited a high expression correlation with angiogenesis marker VEGFA.
View Article and Find Full Text PDFLncRNA SCIRT is Downregulated in Acute Myeloid Leukemia and Sponges miR-21 in Cytoplasm to Increase Chemosensitivity to Doxorubicin.
Crit Rev Eukaryot Gene Expr
June 2022
Emergency Center of Hunan Children's Hospital, No. 86 Ziyuan Road, Yuhua District, Changsha City, Hunan Province, 410007, P.R. China.
Background: This study aimed to explore the role of SCIRT in acute myeloid leukemia (AML) and its interaction with miR-21.
Methods: This study included 66 AML patients who were diagnosed with AML and received doxorubicin (Dox) treatment. Bone marrow was isolated from all patients before and after treatment to prepare BM mononuclear cells (BMMNCs).
LncRNA SCIRT is downregulated in atherosclerosis and suppresses the proliferation of human aortic smooth muscle cells (HAOSMCs) by sponging miR-146a in cytoplasm.
J Cardiothorac Surg
November 2021
Department of Cardiovascular, No. 1 Hospital, Ningbo, Zhejiang Province, People's Republic of China.
Background: SCIRT has been characterized as a key player in cancer biology, while its role in other human diseases is unclear. This study explored its role in atherosclerosis, with a specific focus on its interaction with SCIRT and miR-146a.
Methods: The expression of SCIRT and miR-146a in atherosclerosis-affected tissues and healthy tissues from 56 atherosclerosis patients were analyzed by RT-qPCR.
LncRNA SCIRT absorbs miR-221 to advance the expression of lncRNA GAS5 in oral squamous cell carcinoma to inhibit cancer cell apoptosis.
J Oral Pathol Med
March 2022
Department of Stomatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Background: Although SCIRT has been reported to suppress breast cancer, its role in other cancers, such as oral squamous cell carcinoma (OSCC), is hardly known. We predicted that SCIRT might interact with miR-221 to target lncRNA GAS5 and analyzed the interaction between SCIRT and miR-221 in OSCC.
Methods: SCIRT and miR-221 expression levels were quantified using RT-qPCR.
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