Electrochemical decarboxylation of aryloxyacetic acids followed by fluorination provides easy access to fluoromethyl aryl ethers. This electrochemical fluorodecarboxylation offers a sustainable approach with electric current as traceless oxidant. Using EtN·5HF as fluoride source and as supporting electrolyte, this simple electrosynthesis affords various fluoromethoxyarenes in yields up to 85%.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159297 | PMC |
http://dx.doi.org/10.1039/d0sc02417a | DOI Listing |
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