We herein report the synthesis and biological and computational evaluation of 12 linear analogues of the cyclic lipopeptide battacin, enabled by Cysteine Lipidation on a Peptide or Amino Acid (CLipPA) technology. Several of the novel "CLipP"ed lipopeptides exhibited low micromolar MICs and MBCs against both Gram-negative and Gram-positive bacteria. The mechanism of action was then simulated with the MIC data using computational methods.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159387 | PMC |
| http://dx.doi.org/10.1039/d0sc01814g | DOI Listing |
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