Background: Given the increase in antimicrobial drug resistance of several pathogens that affect the ear, there is a need for alternative therapy for canine otitis externa (OE). We hypothesised that the efficacy of modified Burow's solution would be non-inferior to that of standard treatment with Surolan.
Methods: The treatment success rate of a topical aluminum acetate 2% and betamethasone 0.1% (modified Burow's) otic solution was compared with that of a standard topical otic treatment of polymyxin B sulfate, prednisolone acetate and miconazole (Surolan) suspension in a prospective, open-label clinical trial. For 10 days, 142 dogs (232 ears) with OE were treated with modified Burow's solution or Surolan. The primary study endpoint was the cure rate at 10 days. Clinical efficacy was analysed as a secondary endpoint but without assessment for non-inferiority.
Results: The 10-day OE cure rate was 65% and 59% in the Burow's and Surolan groups, respectively. The modified Burow's solution was non-inferior to Surolan at a non-inferiority margin of -11.5% and was more clinically effective than Surolan in dogs with OE caused by yeast or bacteria.
Conclusion: The results of this study demonstrate that modified Burow's solution is an effective treatment for OE in dogs.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/vetr.503 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Large Cheek Defect Reconstruction With a Rhomboid Flap and Burow's Advancement Flap After Excision of a Basal Cell Carcinoma.
Actas Dermosifiliogr
September 2023
Servicio de dermatología, Hospital de Clínicas Dr. Manuel Quintela, Montevideo, Uruguay.
Reconstruction of large surgical defects on the cheek can be challenging for dermatologic surgeons. We describe using a modified rhomboid flap and Burow's advancement flap to close a surgical defect resulting from the excision of a basal cell carcinoma measuring 10×10cm in the buccomandibular area of the cheek.
View Article and Find Full Text PDFUse of a modified Burow's solution to treat canine otitis externa: A randomised comparative clinical study.
Vet Rec
February 2022
Vellore Village Pet Hospital, Vaughan, Ontario, Canada.
Background: Given the increase in antimicrobial drug resistance of several pathogens that affect the ear, there is a need for alternative therapy for canine otitis externa (OE). We hypothesised that the efficacy of modified Burow's solution would be non-inferior to that of standard treatment with Surolan.
Methods: The treatment success rate of a topical aluminum acetate 2% and betamethasone 0.
Heterologous microProtein expression identifies LITTLE NINJA, a dominant regulator of jasmonic acid signaling.
Proc Natl Acad Sci U S A
October 2020
Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark;
MicroProteins are small, often single-domain proteins that are sequence-related to larger, often multidomain proteins. Here, we used a combination of comparative genomics and heterologous synthetic misexpression to isolate functional cereal microProtein regulators. Our approach identified LITTLE NINJA (LNJ), a microProtein that acts as a modulator of jasmonic acid (JA) signaling.
View Article and Find Full Text PDFPrevalence and characteristics of headache attributed to ingestion or inhalation of a cold stimulus (HICS): A cross-sectional study.
Cephalalgia
March 2020
Department of Neurology, Martin-Luther-University Halle-Wittenberg, Halle/Saale, Germany.
Background: Headache attributed to ingestion or inhalation of a cold stimulus (HICS), colloquially called ice-cream headache, is a common form of a primary headache in adults and children. However, previous studies on adults are limited due to the small number of patients. Furthermore, most of the subjects in previous studies had a history of other primary headaches.
View Article and Find Full Text PDFSpecificity of MYB interactions relies on motifs in ordered and disordered contexts.
Nucleic Acids Res
October 2019
DynaMo Center, Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark.
Physical interactions between members of the MYB and bHLH transcription factor (TF) families regulate many important biological processes in plants. Not all reported MYB-bHLH interactions can be explained by the known binding sites in the R3 repeat of the MYB DNA-binding domain. Noteworthy, most of the sequence diversity of MYB TFs lies in their non-MYB regions, which contain orphan small subgroup-defining motifs not yet linked to molecular functions.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!