AI Article Synopsis
- The extracellular matrix (ECM) remodeling plays a crucial role in the development and spread of tumors, facilitating a supportive environment for tumor growth.
- Tumor cells interact dynamically with the ECM, leading to the release of molecules that can serve as potential biomarkers for cancer progression.
- The article emphasizes the need for advanced bioanalytical methods to detect these ECM-derived components, bridging the gap between research and clinical application in cancer treatment.
Article Abstract
The role of the extracellular matrix (ECM) remodeling in tumorigenesis and metastasis is becoming increasingly clear. Cancer development requires that tumor cells recruit a tumor microenvironment permissive for further tumor growth. This is a dynamic process that takes place by a cross-talk between tumor cells and ECM. As a consequence, molecules derived from the ECM changes associated to cancer are released into the bloodstream, representing potential biomarkers of tumor development. This article highlights the importance of developing and improving bioanalytical methods for the detection of ECM remodeling-derived components, as a step forward to translate the basic knowledge about cancer progression into the clinical practice.
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| http://dx.doi.org/10.1007/s00216-021-03416-2 | DOI Listing |
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