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Decreases in Hepatitis C Testing and Treatment During the COVID-19 Pandemic. | LitMetric

AI Article Synopsis

  • The COVID-19 pandemic significantly disrupted healthcare services, leading to reduced hepatitis C virus (HCV) antibody screenings, clinicians' care, and treatment opportunities, resulting in undiagnosed cases potentially advancing to more severe stages and increasing transmission risks.
  • Analysis of data from a national reference laboratory revealed a sharp decline in hepatitis C antibody testing and RNA-positive results during the pandemic months, with testing volume dropping 59% in April 2020 and treatment prescriptions decreasing by 43% in May.
  • To address these challenges, ongoing public health campaigns and outreach programs are essential to restore HCV testing and treatment rates to pre-pandemic levels and work towards eliminating HCV infections.

Article Abstract

Introduction: The COVID-19 pandemic has disrupted healthcare services, reducing opportunities to conduct routine hepatitis C virus antibody screening, clinical care, and treatment. Therefore, people living with undiagnosed hepatitis C virus during the pandemic may later become identified at more advanced stages of the disease, leading to higher morbidity and mortality rates. Further, unidentified hepatitis C virus-infected individuals may continue to unknowingly transmit the virus to others.

Methods: To assess the impact of the COVID-19 pandemic, data were evaluated from a large national reference clinical laboratory and from national estimates of dispensed prescriptions for hepatitis C virus treatment. Investigators estimated the average number of hepatitis C virus antibody tests, hepatitis C virus antibody-positive test results, and hepatitis C virus RNA-positive test results by month in January-July for 2018 and 2019, compared with the same months in 2020. To assess the impact of hepatitis C virus treatment, dispensed hepatitis C virus direct-acting antiretroviral medications were examined for the same time periods. Statistical analyses of trends were performed using negative binomial models.

Results: Compared with the 2018 and 2019 months, hepatitis C virus antibody testing volume decreased 59% during April 2020 and rebounded to a 6% reduction in July 2020. The number of hepatitis C virus RNA-positive results fell by 62% in March 2020 and remained 39% below the baseline by July 2020. For hepatitis C virus treatment, prescriptions decreased 43% in May, 37% in June, and 38% in July relative to the corresponding months in 2018 and 2019.

Conclusions: During the COVID-19 pandemic, continued public health messaging, interventions and outreach programs to restore hepatitis C virus testing and treatment to prepandemic levels, and maintenance of public health efforts to eliminate hepatitis C infections remain important.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8107198PMC
http://dx.doi.org/10.1016/j.amepre.2021.03.011DOI Listing

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