An induced pluripotent stem cell line (EHTJUi003-A) generated from a neonate with c.1377delC mutation in the gene MYBPC3 causing hypertrophic cardiomyopathy.

Wen-Wen Jia Ji-Zhen Lu Lu Zhang Hong-Xia Cao Yi-Yao Qi Han-Yu Zhu Zhi-Hui Bai Shou-Mei Zhang Zhi-Bin Qiao Yan Bao Zhong-Min Liu

Stem Cell Res

Institute for Regenerative Medicine, National Stem Cell Translational Resource Center, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address:

Published: May 2021

Hypertrophic cardiomyopathy (HCM) is an autosomal dominant heart disease. An induced pluripotent stem cell line (EHTJUi003-A) was generated from umbilical cord blood mononuclear cells (UCBMCs) of a female neonate with heterozygous mutation of p.L460Wfs (c.1377delC) in the MYBPC3 gene. This iPSC model offers a very valuable resource to study the pathological mechanism of HCM in vitro.

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http://dx.doi.org/10.1016/j.scr.2021.102328	DOI Listing

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