We have compared the therapeutic effectiveness of a new UVB fluorescent sunlamp, the Philips TL-01 lamp, which emits a narrow peak around 311-312 nm, with the currently used Philips TL-12 lamp, in 10 patients with psoriasis. We also compared the tumour inducing capacity of the two lamps in hairless mice. The therapeutic effect of the TL-01 lamp was superior to that of the TL-12 lamp in nine of the 10 patients. In the mice, the median tumour induction time was significantly longer in animals exposed to the TL-01 lamp. Phototherapy with the new type of lamp requires a higher dose than phototherapy with the usual broadband UVB sources. In practice this means that more lamps are needed in the light cabinet. However, the new lamps appear to provide more effective and safer phototherapy for psoriasis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2133.1988.tb07096.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
What Is New in Narrow-Band Ultraviolet-B Therapy for Vitiligo?
Indian Dermatol Online J
January 2019
Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
Vitiligo is an acquired disorder of skin pigmentation that produces significant psychological impact especially in those with skin of color. Narrow-band ultraviolet B (NB-UVB) therapy, which was first used in vitiligo in 1997 by Westerhof and Nieuweboer-Krobotova, has emerged as one of the safest and most effective therapy for this dermatosis. The light source used for NB-UVB phototherapy is the TL-01 lamp, and the most common model of the NB-UVB phototherapy device is the upright in-office booth or chamber which has 24-48 such lamps.
View Article and Find Full Text PDFPerspectives of the antipsoriatic heliotherapy in Poland.
J Photochem Photobiol B
November 2014
Institute of Geophysics, Polish Academy of Sciences, Warsaw, Poland.
Statistical analysis of the daily course of exposures to TL-01 tube radiation for 93 psoriatic patients from the Medical University of Łódź during 20-day phototherapy shows that the dose of 1 J/cm(2) represents a unit of single exposure necessary for psoriasis healing. This value is converted to the antipsoriatic effective dose of 317.9 J/m(2) using the TL-01 lamp irradiance spectrum and the antipsoriatic action spectrum.
View Article and Find Full Text PDFSuccessful treatment of psoriasis vulgaris with targeted narrow-band ultraviolet B therapy using a new flat-type fluorescent lamp.
Photodermatol Photoimmunol Photomed
October 2011
Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Narrow-band ultraviolet B (NB-UVB) therapy is widely used for refractory skin diseases. Targeted phototherapy is now being used to reduce the number of sessions and to avoid exposing normal skin. We developed a targeted NB-UVB therapy using a flat-type lamp emitting a wavelength similar to that of the TL-01 fluorescent lamp.
View Article and Find Full Text PDFA randomized comparison of methods of selecting narrowband UV-B starting dose to treat chronic psoriasis.
Arch Dermatol
February 2011
Photobiology Unit, Department of Dermatology, Ninewells Hospital & Medical School, Dundee DD1 9SY, Scotland.
Objectives: To compare narrowband UV-B (TL-01 lamp) phototherapy for psoriasis with individual patient starting doses based on minimal erythemal dose (MED) determination vs a standard fixed starting dose and to compare the efficacy of 70% of MED vs 50% of MED starting dose regimens.
Design: Single-center, randomized, double-blind, clinical trial.
Setting: Department of Dermatology, Ninewells Hospital and Medical School, Dundee, Scotland.
[Narrow spectrum (311 nm) phototherapy in treatment of psoriatic nail].
Georgian Med News
February 2009
Ultraviolet B phototherapy is a common treatment for psoriasis. It was determined that wavelengths between 305 and 315 nm have the best therapeutic effect. The aim of this study was the evaluation of efficacy of narrow spectrum (311 nm) phototherapy in the treatment of psoriatic onychia.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!