Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423943 | PMC |
| http://dx.doi.org/10.1007/s12264-021-00728-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics.
J Zhejiang Univ Sci B
April 2024
Department of Neurology and International Institutes of Medicine, the Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu 322000, China.
Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectively innervate the medial part (LHbM) or lateral part (LHbL) of LHb.
View Article and Find Full Text PDFEffect of dynamic interaction of estrous cycle and stress on synaptic transmission and neuronal excitability in the lateral habenula.
FASEB J
December 2024
Department of Biological Sciences, Konkuk University, Seoul, South Korea.
The prevalence of depressive disorders in women has been reported in many countries. However, the cellular mechanisms mediating such sex differences in stress susceptibility remain largely unknown. Previously, we showed that lateral habenula (LHb) neurons are more activated in female mice than in male mice by restraint stress.
View Article and Find Full Text PDFThe lateral habenula is necessary for maternal behavior in the naturally parturient primiparous mouse dam.
eNeuro
December 2024
The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Mammalian parenting is an unusually demanding commitment. How has the reward system been co-opted to ensure parental care? Previous work has implicated the lateral habenula (LHb), an epithalamic nucleus, as a potential intersection of parenting behavior and reward. Here, we examine the role of the LHb in the maternal behavior of naturally parturient primiparous mouse dams.
View Article and Find Full Text PDFReorganization of lateral habenula neuronal connectivity underlies pain-related impairment in spatial memory encoding.
Pain
December 2024
Instituto de Investigação e Inovação em Saúde (i3S), Pain Neurobiology Research Group, Universidade do Porto, Porto, Portugal.
Dysfunctional hyperactivity of the lateral habenula nucleus (LHb) has emerged as a critical marker for pain-related mood impairments. Acting as a central hub, the LHb filters and disseminates pertinent information to other brain structures during learning. However, it is not well understood how intra-LHb activity is altered during cognitive demand under neuropathic pain conditions.
View Article and Find Full Text PDFThe dopaminergic system mediates the lateral habenula-induced autonomic cardiovascular responses.
Front Physiol
November 2024
Department of Neurophysiology, Institute of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
The lateral habenula (LHb) has been implicated in stress coping and autonomic control. The LHb regulates the midbrain system of monoamine neurotransmitters such as dopamine, serotonin, and noradrenaline. However, how the LHb regulates autonomic cardiovascular control in stressful situations is unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!