An efficient intramolecular annulation of Morita-Baylis-Hillman (MBH) alcohols of propiolaldehydes is developed in the presence of ICl or PhSeSePh/PhSSPh-CuCl. This cyclization offers access to a wide variety of iodinated or chalcogenated 3-(chloromethyl)-2-pyrones in good yields. The chloromethyl group of the obtained 2-pyrones has been easily converted to introduce other handy functionalities, which allowed for further transformations to synthesize diverse 2-pyrone containing molecules.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.orglett.1c01466 | DOI Listing |
Publication Analysis
Top Keywords
alcohols propiolaldehydes
8
iodo- chalcogenoannulation
4
chalcogenoannulation morita-baylis-hillman
4
morita-baylis-hillman alcohols
4
propiolaldehydes entry
4
entry functionalized
4
functionalized 2-pyrones
4
2-pyrones efficient
4
efficient intramolecular
4
intramolecular annulation
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!