Biogenic titanium dioxide nanoparticles have unique size, shape and biochemical functional corona that embellish them with the potential to perform therapeutic actions such as anticancer, antimicrobial, antioxidant, larvicidal and photocatalysis by adopting various mechanistic or physiological approaches at the molecular level. We have provided a detailed overview of some of these physiological mechanisms, including disruption of the electron transport chain, DNA fragmentation, mitochondrial damage, induction of apoptosis, disorganization of the plasma membrane, inhibition of ATP synthase activity, suspension of cellular signaling pathways and inhibition of enzymatic activity. The biogenic synthesis of customized titanium dioxide nanoparticles has future application potentials to do breakthroughs in the pharmaceutical sectors to advance precision medicine and to better explain the disease prognosis and treatment strategies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2217/nnm-2021-0020 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Physiological and behavioral effects of titanium dioxide nanoparticle exposure on stingless bee foragers.
J Hazard Mater
January 2025
Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, MG, Brazil. Electronic address:
Bee population decline is associated with various stressors, including exposure to pollutants. Among these, titanium dioxide (TiO), an emerging nanoparticle (NP) pollutant, potentially affects living organisms, including bees. This study evaluates the impact of TiO NPs ingestion (1.
View Article and Find Full Text PDFNanoparticle-Doped Antibacterial and Antifungal Coatings.
Polymers (Basel)
January 2025
Department of Chemical Engineering, Dr B R Ambedkar National Institute of Technology, Jalandhar 144011, Punjab, India.
Antimicrobial polymeric coatings rely not only on their surface functionalities but also on nanoparticles (NPs). Antimicrobial coatings gain their properties from the addition of NPs into a polymeric matrix. NPs that have been used include metal-based NPs, metal oxide NPs, carbon-based nanomaterials, and organic NPs.
View Article and Find Full Text PDFFrom Anatase TiO Nano-Cuboids to Nano-Bipyramids: Influence of Particle Shape on the TiO Photocatalytic Degradation of Emerging Contaminants in Contrasted Water Matrices.
Molecules
January 2025
Departamento de Ingeniería Química y de Materiales, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Water pollution, resulting from industrial effluents, agricultural runoff, and pharmaceutical residues, poses serious threats to ecosystems and human health, highlighting the need for innovative approaches to effective remediation, particularly for non-biodegradable emerging pollutants. This research work explores the influence of shape-controlled nanocrystalline titanium dioxide (TiO NC), synthesized by a simple hydrothermal method, on the photodegradation efficiency of three different classes of emerging environmental pollutants: phenol, pesticides (methomyl), and drugs (sodium diclofenac). Experiments were conducted to assess the influence of the water matrix on treatment efficiency by using ultrapure water and stormwater (basic) collected from an urban drainage system as matrices.
View Article and Find Full Text PDFUV-C and Nanomaterial-Based Approaches for Sulfite-Free Wine Preservation: Effects on Polyphenol Profile and Microbiological Quality.
Molecules
January 2025
Faculty of Civil and Environmental Engineering, West Pomeranian University of Technology in Szczecin, Piastów 50a, 70-311 Szczecin, Poland.
Controlling the microorganisms employed in vinification is a critical factor for successful wine production. Novel methods aimed at lowering sulfites used for wine stabilization are sought. UV-C irradiation has been proposed as an alternative for reducing the viable cell count of microorganisms in wine and grape juice.
View Article and Find Full Text PDFThe Impact of Nanoparticles and Molecular Forms of TiO on the Rhizosphere of Plants in the Example of Common Wheat ( L.)-Shifts in Microbiome Structure and Predicted Microbial Metabolic Functions.
Int J Mol Sci
January 2025
Department of Entomology, Phytopathology and Molecular Diagnostics, University of Warmia and Mazury in Olsztyn, Prawocheńskiego 17, 10-720 Olsztyn, Poland.
This study investigated the effects of various titanium nanoparticles (TiONPs) on the structure, function, and trophic levels of the wheat rhizobiome. In contrast to the typically toxic effects of small nanoparticles (~10 nm), this research focused on molecular TiO and larger nanoparticles, as follows: medium-sized (68 nm, NPs1) and large (>100 nm, NPs2). The results demonstrated significant yet diverse impacts of different TiO forms on the rhizosphere microbiota.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!