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A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording. | LitMetric

A Lubricated Nonimmunogenic Neural Probe for Acute Insertion Trauma Minimization and Long-Term Signal Recording.

Adv Sci (Weinh)

School of Electrical and Electronic Engineering, Yonsei University, Seoul, 03722, Republic of Korea.

Published: August 2021

AI Article Synopsis

  • Brain-machine interfaces (BMIs) can help treat neurological disorders by translating neural information, but their effectiveness is limited by inflammation and signal sensitivity loss over time.
  • Researchers have developed a lubricated surface for these devices to reduce friction during insertion, which decreases the damage to brain tissue and minimizes immune reactions.
  • This innovative surface design results in a 102% increase in measurable signals and extends the functional period of the devices from 8 to 16 weeks, enhancing the longevity of BMIs.

Article Abstract

Brain-machine interfaces (BMIs) that link the brain to a machine are promising for the treatment of neurological disorders through the bi-directional translation of neural information over extended periods. However, the longevity of such implanted devices remains limited by the deterioration of their signal sensitivity over time due to acute inflammation from insertion trauma and chronic inflammation caused by the foreign body reaction. To address this challenge, a lubricated surface is fabricated to minimize friction during insertion and avoid immunogenicity during neural signal recording. Reduced friction force leads to 86% less impulse on the brain tissue, and thus immediately increases the number of measured signal electrodes by 102% upon insertion. Furthermore, the signal measurable period increases from 8 to 16 weeks due to the prevention of gliosis. By significantly reducing insertion damage and the foreign body reaction, the lubricated immune-stealthy probe surface (LIPS) can maximize the longevity of implantable BMIs.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336494PMC
http://dx.doi.org/10.1002/advs.202100231DOI Listing

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