AI Article Synopsis
- F magnetic resonance imaging (F MRI) is an advanced imaging technique that excels in clinical diagnosis but faces challenges in creating effective fluorine agents.
- Researchers developed a novel platform called FILAMP, using fluorinated ionic liquids (ILs), which respond to environmental stimuli to release their fluorine payloads.
- This "turn-on" mechanism allows for enhanced F signals, successfully detecting biological targets at both cellular and animal levels, showcasing its potential for diagnosing and monitoring disease processes.
Article Abstract
F magnetic resonance imaging (F MRI) is a promising technique for molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of F probes with good water solubility and versatile functions for bioresponsive and practical applications remains a challenge. Here, we report fluorinated ion liquids (ILs) as a new type of fluorine agents and build a fluorinated ionic liquid-based activatable F MRI platform (FILAMP), which relies on the phase transition of ILs. Upon exposure to environmental stimulation, coating polymer dissolves or degrades to release the fluorinated ILs payload, which rapidly enhances F signal. This "turn-on" response is verified by the successful detection of biological targets (for example, dysregulated pH and MMP overexpression) at the cellular level and in mice, demonstrating the potential of FILAMP as a robust activatable F probe for diagnosis and monitoring of biological and pathological processes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8171808 | PMC |
| http://dx.doi.org/10.1016/j.chempr.2020.01.023 | DOI Listing |
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